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Heterogeneity of Pulmonary Stem Cells

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Stem Cells Heterogeneity in Different Organs

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1169))

Abstract

Epithelial stem cells reside within multiple regions of the lung where they renew various region-specific cells. In addition, there are multiple routes of regeneration after injury through built-in heterogeneity within stem cell populations and through a capacity for cellular plasticity among differentiated cells. These processes are important facets of respiratory tissue resiliency and organism survival. However, this regenerative capacity is not limitless, and repetitive or chronic injuries, environmental stresses, or underlying factors of disease may ultimately lead to or contribute to tissue remodeling and end-stage lung disease. This chapter will review stem cell heterogeneity among pulmonary epithelia in the lower respiratory system, discuss recent findings that may challenge long-held scientific paradigms, and identify several clinically relevant research opportunities for regenerative medicine.

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Authors and Affiliations

  1. Department of Anatomy and Cell Biology, Division of Cardiothoracic Surgery, Carver College of Medicine, University of Iowa, Iowa City, IA, USA

    Thomas J. Lynch, Vitaly Ievlev & Kalpaj R. Parekh

  2. Department of Surgery, Carver College of Medicine, University of Iowa, Iowa City, IA, USA

    Thomas J. Lynch & Kalpaj R. Parekh

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  1. Thomas J. Lynch
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  2. Vitaly Ievlev
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Correspondence to Kalpaj R. Parekh .

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Editors and Affiliations

  1. Department of Pathology, Federal University of Minas Gerais, Department of Radiology, Columbia University Medical Center, New York, NY, USA, Belo Horizonte, Minas Gerais, Brazil

    Alexander Birbrair

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Lynch, T.J., Ievlev, V., Parekh, K.R. (2019). Heterogeneity of Pulmonary Stem Cells. In: Birbrair, A. (eds) Stem Cells Heterogeneity in Different Organs. Advances in Experimental Medicine and Biology, vol 1169. Springer, Cham. https://doi.org/10.1007/978-3-030-24108-7_6

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