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Heterogeneity of Stem Cells in the Thyroid

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Book cover Stem Cells Heterogeneity in Different Organs

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1169))

Abstract

Identification of thyroid stem cells in the past few years has made important contributions to our understanding of the cellular and molecular mechanisms that induce tissue regeneration and repair. Embryonic stem (ES) cells and induced-pluripotent stem cells have been used to establish reliable protocols to obtain mature thyrocytes and functional follicles for the treatment of thyroid diseases in mice. In addition, the discovery of resident thyroid progenitor cells, along with other sources of stem cells, has defined in detail the mechanisms responsible for tissue repair upon moderate or severe organ injury.

In this chapter, we highlight in detail the current state of research on thyroid stem cells by focusing on (1) the description of the first experiments performed to obtain thyroid follicles from embryonic stem cells, (2) the identification of resident stem cells in the thyroid gland, and (3) the definition of the current translational in vivo and in vitro models used for thyroid tissue repair and regeneration.

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Author information

Authors and Affiliations

  1. Biomedical Department of Internal and Specialist Medicine (DI.BI.MIS), Laboratory of Regenerative Medicine, Section of Endocrinology, Diabetology and Metabolism, University of Palermo, Palermo, Italy

    Giovanni Zito, Antonina Coppola, Giuseppe Pizzolanti & Carla Giordano

  2. Advanced Technologies Network (ATeN) Center, Laboratory of Stem Cells and Cellular Cultures, University of Palermo, Palermo, Italy

    Giovanni Zito, Antonina Coppola, Giuseppe Pizzolanti & Carla Giordano

Authors
  1. Giovanni Zito
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  2. Antonina Coppola
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  3. Giuseppe Pizzolanti
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  4. Carla Giordano
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Correspondence to Carla Giordano .

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Editors and Affiliations

  1. Department of Pathology, Federal University of Minas Gerais, Department of Radiology, Columbia University Medical Center, New York, NY, USA, Belo Horizonte, Minas Gerais, Brazil

    Alexander Birbrair

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Zito, G., Coppola, A., Pizzolanti, G., Giordano, C. (2019). Heterogeneity of Stem Cells in the Thyroid. In: Birbrair, A. (eds) Stem Cells Heterogeneity in Different Organs. Advances in Experimental Medicine and Biology, vol 1169. Springer, Cham. https://doi.org/10.1007/978-3-030-24108-7_5

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