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Stem Cells Heterogeneity in Different Organs pp 195–211Cite as

Hematopoietic Stem Cell Heterogeneity

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1169))

Abstract

Hematopoietic stem cells (HSCs) maintain lifelong production of mature blood cells and regenerate the hematopoietic system after cytotoxic injury. Use of expanding cell surface marker panels and advanced functional analyses have revealed the presence of several immunophenotypically different HSC subsets with distinct self-renewal and repopulating capacity and bias toward selective lineage differentiation. This chapter summarizes current understanding of the phenotypic and functional heterogeneity within the HSC pool, with emphasis on the immunophenotypes and functional features of several known HSC subsets, and their roles in steady-state and emergency hematopoiesis, and in aging. The chapter also highlights some of the future research directions to elucidate further the biology and function of different HSC subsets in health and disease states.

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Authors and Affiliations

  1. Department of Microbiology & Immunology, Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA

    Roland Jurecic

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  1. Roland Jurecic
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Correspondence to Roland Jurecic .

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  1. Department of Pathology, Federal University of Minas Gerais, Department of Radiology, Columbia University Medical Center, New York, NY, USA, Belo Horizonte, Minas Gerais, Brazil

    Alexander Birbrair

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Jurecic, R. (2019). Hematopoietic Stem Cell Heterogeneity. In: Birbrair, A. (eds) Stem Cells Heterogeneity in Different Organs. Advances in Experimental Medicine and Biology, vol 1169. Springer, Cham. https://doi.org/10.1007/978-3-030-24108-7_10

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