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Heterogeneity of Neural Stem Cells in the Ventricular–Subventricular Zone

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Stem Cells Heterogeneity in Different Organs

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1169))

Abstract

In this chapter, heterogeneity is explored in the context of the ventricular–subventricular zone, the largest stem cell niche in the mammalian brain. This niche generates up to 10,000 new neurons daily in adult mice and extends over a large spatial area with dorso-ventral and medio-lateral subdivisions. The stem cells of the ventricular–subventricular zone can be subdivided by their anatomical position and transcriptional profile, and the stem cell lineage can also be further subdivided into stages of pre- and post-natal quiescence and activation. Beyond the stem cells proper, additional differences exist in their interactions with other cellular constituents of the niche, including neurons, vasculature, and cerebrospinal fluid. These variations in stem cell potential and local interactions are discussed, as well as unanswered questions within this system.

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Authors and Affiliations

  1. Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA

    Gabrielle V. Rushing, Madelyn K. Bollig & Rebecca A. Ihrie

  2. Neuroscience Program, Vanderbilt University, Nashville, TN, USA

    Gabrielle V. Rushing, Madelyn K. Bollig & Rebecca A. Ihrie

  3. Department of Neurological Surgery, Vanderbilt University School of Medicine, Nashville, TN, USA

    Rebecca A. Ihrie

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  1. Gabrielle V. Rushing
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  2. Madelyn K. Bollig
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  3. Rebecca A. Ihrie
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Correspondence to Rebecca A. Ihrie .

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  1. Department of Pathology, Federal University of Minas Gerais, Department of Radiology, Columbia University Medical Center, New York, NY, USA, Belo Horizonte, Minas Gerais, Brazil

    Alexander Birbrair

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Rushing, G.V., Bollig, M.K., Ihrie, R.A. (2019). Heterogeneity of Neural Stem Cells in the Ventricular–Subventricular Zone. In: Birbrair, A. (eds) Stem Cells Heterogeneity in Different Organs. Advances in Experimental Medicine and Biology, vol 1169. Springer, Cham. https://doi.org/10.1007/978-3-030-24108-7_1

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