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Leveraging Antimicrobial Stewardship: Focus on Individual Prescriptions Appropriateness

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Health and Social Care Systems of the Future: Demographic Changes, Digital Age and Human Factors (HEPS 2019)

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Abstract

Antimicrobial resistance and healthcare associated infections are major worldwide Public Health and Patient Safety challenges. Inappropriate antibiotic prescription is the major drive for antibiotic resistance and is present in 30 to 50% of all antibiotic prescriptions. However, adherence to guidelines and to computerized decision support systems is still poor, reflecting the complexity of the prescription process. Antimicrobial stewardship programs have been implemented aiming optimization of prescriptions. Assessment of individual prescriptions appropriateness is a major task and a pillar of these programs. Adoption of universal definitions of appropriateness and assessments, based on quality indicators, metrics and algorithms, is needed in order to improve classifications of individual prescriptions and its determinants, where new eHealth tools and ultimately artificial intelligence will be major allies. This text highlights the importance of evaluation of individual prescriptions as the major way to understand the determinants of (in)appropriate antibiotic prescription and the need for future developments. It mainly results from a comprehensive review of papers published since 2010, related to antimicrobial resistance, the prescription process, antimicrobial stewardship, as well the appropriateness of antibiotic prescription and its evaluation. The road is ahead!

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References

  1. Manning, M.L., Septimus, E.J., Ashley, E.S.D.: Antimicrobial stewardship and infection prevention-leveraging the synergy: a position paper update. Am. J. Infect. Control 46, 364–368 (2018)

    Article  Google Scholar 

  2. OECD. Stemming the Superbug Tide: Just A Few Dollars More. OECD Publishing (2018). https://doi.org/10.1787/9789264307599-en

  3. O’Neill, J.: Tackling Drug-Resistant Infections Globally: Final Report and Recommendations. Wellcome Trust (2016)

    Google Scholar 

  4. A European One Health Action Plan against Antimicrobial Resistance (AMR). European Community (2017)

    Google Scholar 

  5. National Action Plan for Combating Antibiotic-Resistant Bacteria. The White House (2015)

    Google Scholar 

  6. Global Action Plan on Antimicrobial Resistance. WHO (2015)

    Google Scholar 

  7. National Institute of Allergy and Infectious Diseases. https://www.niaid.nih.gov/research/antimicrobial-resistance-definitions

  8. D’Costa, V., et al.: Antibiotic resistance is ancient. Nature 457 (2011). https://doi.org/10.1038/nature10388

    Article  Google Scholar 

  9. Courvalin, P.: Why is antibiotic resistance a deadly emerging disease? Clin. Microbiol. Infect. 22(5), 405–407 (2016). https://doi.org/10.1016/j.cmi.2016.01.012

    Article  Google Scholar 

  10. WHO Europe. Fact sheets on sustainable development goals: health targets. WHO (2017)

    Google Scholar 

  11. Jasovský, D., Littmann, J., Zorzet, A., Cars, O.: Antimicrobial resistance—a threat to the world’s sustainable development. Upsala J. Med. Sci. 121(3), 159–164 (2016). https://doi.org/10.1080/03009734.2016.1195900

    Article  Google Scholar 

  12. Discussion Draft: DRUG-Resistant Infections. A Threat to Our Economic Future. The World Bank (2016)

    Google Scholar 

  13. Laxminarayan, R.: Antimicrobials: access and sustainable effectiveness 1. Access to effective antimicrobials: a worldwide challenge. Lancet 387:168–175 (2016)

    Article  Google Scholar 

  14. Pruden, A., et al.: Management options for reducing the release of antibiotics and antibiotic resistance genes to the environment. Environ. Health Perspect. 121, 878–885 (2013). https://doi.org/10.1289/ehp.1206446

    Article  Google Scholar 

  15. Nutbeam, D.: Health literacy as a public health goal: a challenge for contemporary health education and communication strategies into the 21st century. Health Promot. Int. 15(3), 259–267

    Article  Google Scholar 

  16. Fleming-Dutra, K., et al.: Prevalence of inappropriate antibiotic prescriptions among US ambulatory care visits, 2010–2011. JAMA 315(17), 1864–1873 (2016)

    Article  Google Scholar 

  17. Special Eurobarometer 445 on Antimicrobial Resistance. European Community, Apr 2016

    Google Scholar 

  18. Singer, M., Deutschman, C.S., Seymour, C.W., et al.: The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 315, 801–810 (2016). https://doi.org/10.1001/jama.2016.0287)

    Article  Google Scholar 

  19. Subbe, C.P., Kruger, M., Rutherford, P., et al.: Validation of a modified early warning score in medical admissions. QJM. 94, 521–526 (2001). https://doi.org/10.1093/qjmed/94.10.52

  20. Póvoa, P., Teixeira-Pinto, A.M., Carneiro, A.H., António, H.C.: C-reactive protein, an early marker of community acquired sepsis resolution: a multi-center prospective observational study. Crit. Care 15, R169 (2011)

    Article  Google Scholar 

  21. Linder, J.A., Meeker, D., Doctor, J.N., Friedberg, M.W., et al.: Time of day and the decision to prescribe antibiotics. JAMA Intern. Med. 174(12), 2029–2031 (2014). https://doi.org/10.1001/jamainternmed.2014.5225

    Article  Google Scholar 

  22. Parker, H.M., et al.: The determinants of antimicrobial prescribing among hospital doctors in England: a framework to inform tailored stewardship interventions. Br. J. Clin. Pharmacol. 82(2), 431–440 (2016). https://doi.org/10.1111/bcp.12953

    Article  Google Scholar 

  23. Gianino, M.M., Lenzi, J., Bonaudo, M., et al.: Predictors and trajectories of antibiotic consumption in 22 EU countries: findings from a time series analysis (2000–2014). PLoS One 13(6), e0199436 (2018). https://doi.org/10.1371/journal.pone.0199436.)

    Article  Google Scholar 

  24. Rodrigues, A.T., Roque, F., Falcão, A.: Understanding physician antibiotic prescribing behavior: a systematic review of qualitative studies. Antimicrob. Agents 41, 203–212 (2013)

    Article  Google Scholar 

  25. Salmi, R., Rezal, R.S.M., Hassali, M.A., Alrasheedy, A.A., et al.: Physicians’ knowledge, perceptions and behavior towards antibiotic prescribing: a systematic review of the literature. Expert Rev. Anti Infect. Ther. 13(5), 665–680 (2015)

    Article  Google Scholar 

  26. Borg, M.: Cultural determinants of infection control behaviour: understanding drivers and implementing effective change. J. Hosp. Infect. 86, 161–168 (2014)

    Article  Google Scholar 

  27. Heath, C., Switch, H.D.: How to Change Things when Change is Hard. Random House Canada (2010)

    Google Scholar 

  28. Michie, S., van Stralen, M.M., West, R.: The behaviour change wheel: a new method for characterising and designing behaviour change interventions. Implement. Sci. 6, 42 (2011)

    Google Scholar 

  29. Core Elements of Hospital Antibiotic Stewardship Programs. Department of Health and Human Services, CDC (2014). http://www.cdc.gov/getsmart/healthcare/implementation/core-elements.html

  30. Dyar, O.J., Huttner, B., Schouten, J., et al.: What is antimicrobial stewardship? Clin. Microbiol. Infect. 23, 793 (2017)

    Article  Google Scholar 

  31. Shojania, K.G., Duncan, B.W., Stanford, K.M., et al.: Making health care safer: a critical analysis of patient safety practices. Evid. Rep. Technol. Assess. 43 (2001). AHQR 2001

    Google Scholar 

  32. WHO. Medication Without Harm - Global Patient Safety Challenge on Medication Safety. Geneva: World Health Organization 2017. Licence: CC BY-NC-SA 3.0 IGO (2017)

    Google Scholar 

  33. Tamma, P.D., Holmes, A., Asley, E.D.: Antimicrobial stewardship: another focus for patient safety? Curr. Opin. Infect. Dis. 2, 348–355 (2014)

    Article  Google Scholar 

  34. Timbrook, T.T., Hurst, J.M., Bosso, J.A.: Impact of an antimicrobial stewardship program on antimicrobial utilization, bacterial susceptibilities, and financial expenditures at an academic medical center. Hosp. Pharm. 51, 703–711 (2016)

    Article  Google Scholar 

  35. Cabana, M.D., Rand, C.S., Powe, N.R., et al.: Why don’t physicians follow clinical practice guidelines? A framework for improvement. JAMA 282, 1458–1465 (1999)

    Article  Google Scholar 

  36. Lugtenberg, M., Burgers, J.S., Besters, C.F., et al.: Perceived barriers to guideline adherence: a survey among general practitioners. BMC Fam. Pract. 12, 98 (2011). http://www.biomedcentral.com/1471-2296/12/98

  37. Black, A.D., Car, J., Pagliari, C., Anandan, C., Cresswell, K., et al.: The impact of eHealth on the quality and safety of health care: a systematic overview. PLoS Med. 8(1), e1000387 (2011). https://doi.org/10.1371/journal.pmed.1000387

    Article  Google Scholar 

  38. Curtis, C.E., Bahar, F.A., Marriot, J.F.: The effectiveness of computerised decision support on antibiotic use in hospitals. A systematic review. PLoS One 12(8), e0183062. https://doi.org/10.1371/journal.pone.0183062

    Article  Google Scholar 

  39. Palos, C., Pedroso, A., Mapril, J., Alves, C.: Building up an infection control strategy based on the e-health concept. Critic. Care 14(Suppl. 2), P51 (2010)

    Article  Google Scholar 

  40. Chow, A.L.P., Lye, D.C., Arah, O.A.: Patient and physician predictors of patient receipt of therapies recommended by a computerized decision support system when initially prescribed broad-spectrum antibiotics: a cohort study. J. Am. Med. Inform. Assoc., 1–13 (2015). https://doi.org/10.1093/jamia/ocv120

    Article  Google Scholar 

  41. Baysari, M.T., Oliver, K., Egan, B., Li, L., Richardson, K., Sandaradura, I., Westbrook, J.I., Day, R.O.: The effectiveness of information technology to improve antimicrobial prescribing in hospitals: a systematic review and meta-analysis. Int. J. Med. Inform. 92, 15–34 (2016)

    Article  Google Scholar 

  42. Cresswell, K., Mozaffara, H., Shahb, S., Sheikha, A.: Approaches to promoting the appropriate use of antibiotics through hospital electronic prescribing systems: a scoping review. Int. J. Pharm. Pract. 25, 5–17 (2017). https://doi.org/10.1111/ijpp.12274

    Article  Google Scholar 

  43. Davey, P., Marwick, C.A., Scott, C.L.: Interventions to improve antibiotic prescribing practices for hospital inpatients. Cochrane Database Syst. Rev. (2). Art. No.: CD003543 (2017). https://doi.org/10.1002/14651858.cd003543.pub4

  44. Buetow, S.A., Sibbald, B., Cantrill, J.A., et al.: Appropriateness in health care: application to prescribing. Soc. Sci. Med. 45(2), 261–271 (1997)

    Article  Google Scholar 

  45. World Health Organization. The Rational Use of Drugs. Report of the Conference of Experts. http://apps.who.int/medicinedocs/documents/s17054e/s17054e.pdf

  46. World Health Organization. The Pursuit of Responsible Use of Medicines: Sharing and Learning from Country Experiences. http://apps.who.int/iris/bitstream/10665/75828/1/WHO_EMP_MAR_2012.3_eng.pdf

  47. van der Meer, J., Gyssens, I.: Quality of antimicrobial drug prescription in hospital. Clin. Microbiol. Infect. 7(Supplement 6), 12–15 (2001)

    Article  Google Scholar 

  48. Proposals for EU guidelines on the prudent use of antimicrobials in humans Technical Report. ECDC (2017)

    Google Scholar 

  49. Spivak, E., Cosgrove, S.E., Srinivasan, A.: Measuring appropriate antimicrobial use: attempts at opening the black box. CID 63(12), 1639–1644 (2016)

    Article  Google Scholar 

  50. DePestel, D., Eiland, E.H., Lusardi, K.: Assessing appropriateness of antimicrobial therapy: in the eye of the interpreter. CID 59(S3), S154–S161 (2014)

    Article  Google Scholar 

  51. Monnier, A., Eisenstein, B.I., Hulscher, E.: Towards a global definition of responsible antibiotic use: results of an international multidisciplinary consensus procedure. J. Antimicrob. Chemother. 73(Suppl. 6), vi3–vi16 (2018)

    Article  Google Scholar 

  52. Monnier, A., Schouten, J., Le Maréchal, M., et al.: Quality indicators for responsible antibiotic use in the inpatient setting: a systematic review followed by an international multidisciplinary consensus procedure. J. Antimicrob. Chemother. 73(Suppl. 6), vi30–vi39 (2018). https://doi.org/10.1093/jac/dky116

    Article  Google Scholar 

  53. ECDC, EFSA and EMA Joint Scientific Opinion on a list of outcome indicators as regards surveillance of antimicrobial resistance and antimicrobial consumption in humans and food-producing animals. EFSA J. 15(10), 5017 (2017)

    Google Scholar 

  54. Hermsen, E.D., VanSchooneveld, T.C., Sayles, H., Rupp, M.E.: Implementation of a clinical decision support system for antimicrobial stewardship. Infect. Control Hosp. Epidemiol. 33(4), 412–415 (2012)

    Article  Google Scholar 

  55. Palos, C., Bispo, A., Rodrigues, P., França, L., Capoulas, M.: Optimizing antimicrobial prescription through e-health: setting, dosing, timing and stewardship. Antimicrob. Resist. Infect. Control 4(Suppl. 1), O3 (2015). https://doi.org/10.1186/2047-2994-4-S1-O3

    Article  Google Scholar 

  56. Beaudoin, M., Kabanza, F., Nault, V., Valliquette, L.: An antimicrobial prescription surveillance system that learns from experience. In: Proceedings of the Twenty-Fifth Innovative Applications of Artificial Intelligence Conference, pp. 1451–1458 (2013)

    Google Scholar 

  57. Parfit, E.C.T., Valiquette, L., Laupland, K.B.: When it comes to stewardship, it’s time to get with the programmers. Can. J. Infect. Dis. Med. Microbiol. 26(5), 234–236 (2015)

    Article  Google Scholar 

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Palos, C., Sousa, P. (2019). Leveraging Antimicrobial Stewardship: Focus on Individual Prescriptions Appropriateness. In: Cotrim, T., Serranheira, F., Sousa, P., Hignett, S., Albolino, S., Tartaglia, R. (eds) Health and Social Care Systems of the Future: Demographic Changes, Digital Age and Human Factors. HEPS 2019. Advances in Intelligent Systems and Computing, vol 1012. Springer, Cham. https://doi.org/10.1007/978-3-030-24067-7_15

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