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Autophagy and Tumorigenesis in Drosophila

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The Drosophila Model in Cancer

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1167))

  • The original version of this chapter was revised: The co-author’s name was incorrectly spelled as “Royjar” instead of “Rojyar” which has been corrected now. The correction to this chapter is available at https://doi.org/10.1007/978-3-030-23629-8_15

Abstract

The resurgence of Drosophila as a recognized model for carcinogenesis has contributed greatly to our conceptual advance and mechanistic understanding of tumor growth in vivo. With its powerful genetics, Drosophila has emerged as a prime model organism to study cell biology and physiological functions of autophagy. This has enabled exploration of the contributions of autophagy in several tumor models. Here we review the literature of autophagy related to tumorigenesis in Drosophila. Functional analysis of core autophagy components does not provide proof for a classical tumor suppression role for autophagy alone. Autophagy both serve to suppress or support tumor growth. These effects are context-specific, depending on cell type and oncogenic or tumor suppressive lesion. Future delineation of how autophagy impinges on tumorigenesis will demand to untangle in detail, the regulation and flux of autophagy in the respective tumor models. The downstream tumor-regulative roles of autophagy through organelle homeostasis, metabolism, selective autophagy or alternative mechanisms remain largely unexplored.

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Change history

  • 12 December 2020

    The chapter was inadvertently published with one of the co-author’s name incorrectly spelled as “Royjar” instead of “Rojyar”. This error has now been corrected to read as “Rojyar Khezri”.

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Author information

Authors and Affiliations

  1. Center for Cancer Cell Reprogramming (CanCell), Institute for Clinical Medicine, The Medical Faculty, University of Oslo, Oslo, Norway

    Rojyar Khezri & Tor Erik Rusten

  2. Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway

    Rojyar Khezri & Tor Erik Rusten

Authors
  1. Rojyar Khezri
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  2. Tor Erik Rusten
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Correspondence to Tor Erik Rusten .

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Editors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Tulane Cancer Center, LCRC, Tulane University School of Medicine, New Orleans, LA, USA

    Wu-Min Deng

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Khezri, R., Rusten, T.E. (2019). Autophagy and Tumorigenesis in Drosophila. In: Deng, WM. (eds) The Drosophila Model in Cancer. Advances in Experimental Medicine and Biology, vol 1167. Springer, Cham. https://doi.org/10.1007/978-3-030-23629-8_7

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