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Dynamic 18F-Fluoride Imaging

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Sodium Fluoride PET/CT in Clinical Use

Abstract

Diseases affecting bone metabolism involve a wide range of skeletal and soft tissue disorders. They may be grouped as osteoporosis, osteomalacia, hyperparathyroidism, Paget’s disease of bone, and developmental disorders of bone. Age-related osteoporosis alone affects about 28 million Americans, and the cost of caring for osteoporosis-related fractures has recently been estimated to be about $14.8 billion each year.

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References

  1. Blake GM, Puri T, Siddique M, Frost ML, Moore AEB, Fogelman I. Site specific measurements of bone formation using [18F] sodium fluoride PET/CT. Quant Imaging Med Surg. 2018;8(1):47–59. https://doi.org/10.21037/qims.2018.01.02.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Hawkins RA, Choi Y, Huang SC, Hoh CK, Dahlbom M, Schiepers C, Satyamurthy N, Barrio JR, Phelps ME. Evaluation of the skeletal kinetics of fluorine-18-fluoride ion with PET. J Nucl Med. 1992;33:633–42.

    CAS  PubMed  Google Scholar 

  3. Blake GM, Siddique M, Puri T, Frost ML, Moore AE, Cook GJ, Fogelman I. A semipopulation input function for quantifying static and dynamic 18F-fluoride PET scans. Nucl Med Commun. 2012;33:881–8.

    Article  PubMed  Google Scholar 

  4. Siddique M, Frost ML, Moore AE, Fogelman I, Blake GM. Correcting 18F-fluoride PET static scan measurements of skeletal plasma clearance for tracer efflux from bone. Nucl Med Commun. 2014;35:303–10.

    Article  CAS  PubMed  Google Scholar 

  5. Sachpekidis C, Hillengass J, Goldschmidt H, Anwar H, Haberkorn U, Dimitrakopoulou-Strauss A. Quantitative analysis of 18F-NaF dynamic PET/CT cannot differentiate malignant from benign lesions in multiple myeloma. Am J Nucl Med Mol Imaging. 2017;7(4):148–56.

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Sachpekidis C, Hillengass J, Goldschmidt H3, Wagner B, Haberkorn U, Kopka K, Dimitrakopoulou-Strauss A. Treatment response evaluation with 18F-FDG PET/CT and 18F-NaF PET/CT in multiple myeloma patients undergoing high-dose chemotherapy and autologous stem cell transplantation. Eur J Nucl Med Mol Imaging. 2017;44(1):50–62.

    Article  CAS  PubMed  Google Scholar 

  7. Simoncic U, Perlman S, Liu G, Staab MJ, Straus JE, Jeraj R. Comparison of NaF and FDG PET/CT for assessment of treatment response in castration-resistant prostate cancers with osseous metastases. Clin Genitourin Cancer. 2015;13(1):e7–e17. https://doi.org/10.1016/j.clgc.2014.07.001.

    Article  PubMed  Google Scholar 

  8. Jenkins NW, Talbott JF, Shah V, Pandit P, Seo Y, Dillon WP, Majumdar S. [18F]-sodium fluoride PET MR-based localization and quantification of bone turnover as a biomarker for facet joint-induced disability. AJNR Am J Neuroradiol. 2017;38(10):2028–31. https://doi.org/10.3174/ajnr.A5348.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Adesanya O, Sprowson A, Masters J, Hutchinson C. Review of the role of dynamic 18F-NaF PET in diagnosing and distinguishing between septic and aseptic loosening in hip prosthesis. J Orthop Surg Res. 2015;10:5. https://doi.org/10.1186/s13018-014-0147-7.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Freesmeyer M, Stecker FF, Schierz JH, Hofmann GO, Winkens T. First experience with early dynamic (18)F-NaF-PET/CT in patients with chronic osteomyelitis. Ann Nucl Med. 2014;28(4):314–21. https://doi.org/10.1007/s12149-014-0810-4.

    Article  CAS  PubMed  Google Scholar 

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Macapinlac, H.A., Kairemo, K. (2020). Dynamic 18F-Fluoride Imaging. In: Kairemo, K., Macapinlac, H.A. (eds) Sodium Fluoride PET/CT in Clinical Use. Clinicians’ Guides to Radionuclide Hybrid Imaging(). Springer, Cham. https://doi.org/10.1007/978-3-030-23577-2_7

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  • DOI: https://doi.org/10.1007/978-3-030-23577-2_7

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-23576-5

  • Online ISBN: 978-3-030-23577-2

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