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18F Sodium Fluoride: Tracer and Technique

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Book cover Sodium Fluoride PET/CT in Clinical Use

Part of the book series: Clinicians’ Guides to Radionuclide Hybrid Imaging ((PET/CT))

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Abstract

The first images of the bones of the skeleton date back to the late 1890s when German physicist Wilhelm Röntgen produced the first plain film by projecting X-rays through his wife’s hand to produce a picture of the hand bones on a photographic plate [1, 2]. We have come a long way since the 1890s.

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References

  1. Rontgen WK. Ueber eine neue Art von Strahlen (on a new kind of rays). Sitzungsberichte der Würzburger Physik-medic. Gesellschaft. 1895 [translation from Nature 53: 274–276, 1896].

    Google Scholar 

  2. Thomas AMK, Banerjee AK. The history of radiology. Cary: Oxford University Press; 2013.

    Book  Google Scholar 

  3. Blau M, Nagler W, Bender M. Fluorine-18: a new isotope for bone scanning. J Nucl Med. 1962;3:332–4.

    CAS  PubMed  Google Scholar 

  4. Cassen B, Curtis L, Reed C, Libby R. Instrumentation for 131I use in medical studies. Nucleonics. 1951;9:46–50.

    Google Scholar 

  5. Williams LE. Anniversary paper: nuclear medicine: fifty years and still counting. Med Phys. 2008;35(7):3020–9. https://doi.org/10.1118/1.2936217.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Anger HO. Use of a gamma-ray pinhole camera for in vivo studies. Nature. 1952;170:200–1.

    Article  CAS  PubMed  Google Scholar 

  7. Fowler JS, Wolf AP. The synthesis of carbon-11, fluorine-18 and nitrogen-13 labeled radiotracers for biomedical applications, National Academy of Sciences—National Research Council. Nuclear Science Series: Monographs. Upton: Brookhaven National Lab; 1982.

    Google Scholar 

  8. Yano Y, Van Dyke DC, Verdon TA Jr, Anger HO. Cyclotron-produced 157Dy compared with 18F for bone scanning using the whole-body scanner and scintillation camera. J Nucl Med. 1971 Dec;12(12):815–21.

    Google Scholar 

  9. Powsner ER, Palmer MR, Powsner RA. Essentials of nuclear medicine physics and instrumentation. 3rd ed. Hoboken: Wiley; 2013.

    Book  Google Scholar 

  10. Tucker WD, Greene MW, Weis AJ, Murrenhoff A. Methods of preparation of some carrier-free radioisotopes involving sorption on alumina. Upton: Brookhaven National Lab; 1958.

    Book  Google Scholar 

  11. Stang LG Jr, Tucker WD, Doering RF, Weiss AJ, Greene MW, Banks HO Jr. Development of methods for the production of certain short-lived radioisotopes. Int J Appl Radiat Isot. 1957;2:252. https://doi.org/10.1016/0020-708X(57)90233-8.

    Article  Google Scholar 

  12. Harper PV, Lathrop KA, Jiminez F, Fink R, Gottschalk A. Technetium—99m as a scanning agent. Radiology. 1965;85:101.

    Article  CAS  PubMed  Google Scholar 

  13. Clark JC, Silvesterj DJ. A cyclotron method for the production of Fluorine-18. Int J Appl Radiat. 1966;17:151.

    Article  CAS  PubMed  Google Scholar 

  14. Carlson CH, Armstrong WD, Singer L. Distribution, migration and binding of whole blood fluoride evaluated with radiofluoride. Am J Phys. 1960;199:187–9.

    Article  CAS  Google Scholar 

  15. Weber DA, Greenberg EJ, Dimich A, et al. Kinetics of radionuclides used for bone studies. J Nucl Med. 1969;10:8–17.

    CAS  PubMed  Google Scholar 

  16. Hawkins RA, Choi Y, Huang SC, et al. Evaluation of the skeletal kinetics of fluorine-18-fluoride ion with PET. J Nucl Med. 1992;33:633–42.

    CAS  PubMed  Google Scholar 

  17. Subramanian G, McAfee J. A new complex of 99mTc for skeletal imaging. Radiology. 1971;99:192–6.

    Article  CAS  PubMed  Google Scholar 

  18. Phelps ME, Hoffman EJ, Mullani NA, Ter-Pogossian MM. Application of annihilation coincidence detection to transaxial reconstruction tomography. J Nucl Med. 1975;16:210–24.

    CAS  PubMed  Google Scholar 

  19. Pacák J, Točík Z, Černý M. Synthesis of 2-deoxy-2-fluoro-d-glucose. J Chem Soc D. 1969;2:77.

    Article  Google Scholar 

  20. Ido T, Wan CN, Casella V, Fowler JS, Wolf AP, Reivich M, Kuhl DE. Labeled 2-deoxy-d-glucose analogs. 18F-labeled 2-deoxy-2-fluoro-d-glucose, 2-deoxy-2-fluoro-d-mannose and 14C-2-deoxy-2-fluoro-d-glucose. J Labelled Compd Radiopharm. 1978;24:174–83.

    Google Scholar 

  21. Gogvadze V, Zhivotovsky B, Orrenius S. The Warburg effect and mitochondrial stability in cancer cells. Mol Aspects Med. 2010;31(1):60–74.

    Article  CAS  PubMed  Google Scholar 

  22. Mohammadi H. Professor Abass Alavi, distinguished medical scientist. Arch Iran Med. 2015;18:458–60.

    PubMed  Google Scholar 

  23. Townsend DW, Wensveen M, Byars LG. A rotating PET scanner using BGO block detectors: design, performance and applications. J Nucl Med. 1993;34:1367–76.

    CAS  PubMed  Google Scholar 

  24. Beyer T, Townsend DW, Brun T. A combined PET/CT scanner for clinical oncology. J Nucl Med. 2000;41:1369–79.

    CAS  PubMed  Google Scholar 

  25. Joshi NV, Vesey A, Williams MC, Shah AS, Newby DE, et al. 18F-fluoride positron emission tomography for identification of ruptured and high-risk coronary atherosclerotic plaques: a prospective clinical trial. Lancet. 2014;383(9918):705–13.

    Article  PubMed  Google Scholar 

  26. Forsythe RO, Dweck MR, McBride OMB, et al. 18F–sodium fluoride uptake in abdominal aortic aneurysms: the SoFIA3 study. J Am Coll Cardiol. 2018;71(5):513–23.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Czernin J, Satyamurthy N, Schiepers C. Molecular mechanisms of bone 18F-NaF deposition. J Nucl Med. 2010;51(12):1826–9.

    Article  CAS  PubMed  Google Scholar 

  28. Fogelman I, Cook G, Israel O, Van der Wall H. Positron emission tomography and bone metastases. Semin Nucl Med. 2005;35:135–42.

    Article  PubMed  Google Scholar 

  29. Ordonez AA, DeMarco VP, Klunk MH, Pokkali S, Jain SK. Imaging chronic tuberculous lesions using sodium (18F) fluoride positron emission tomography in mice. Mol Imaging Biol. 2015;17(5):609–14.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Iagaru AH, Mittra E, Colletti PM, Jadvar H. Bone-targeted imaging and radionuclide therapy in prostate Cancer. J Nucl Med. 2016;57(Suppl 3):19S–24S.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Segall G, Delbeke D, Stabin MG, Even-Sapir E, Fair J, Sajdak R, Smith GT. SNM practice guideline for sodium 18F-fluoride PET/CT bone scans 1.0. J Nucl Med. 2010;51(11):1813–20.

    Article  PubMed  Google Scholar 

  32. Beheshti M, Mottaghy FM, Paycha F, Behrendt FFF, Van den Wyngaert T, Fogelman I, Strobel K, Celli M, Fanti S, Giammarile F, Krause B, Langsteger W. 18F-NaF PET/CT: EANM procedure guidelines for bone imaging. Eur J Nucl Med Mol Imaging. 2015;42:1767.

    Article  CAS  PubMed  Google Scholar 

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Acknowledgment

I would like to thank Richelle D. Millican, Positron Emission Tomography Manager at MD Anderson Cancer Center, for her expert contribution to the PET imaging protocol section of this chapter.

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Authors and Affiliations

  1. Department of Nuclear Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Lesley Flynt

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  1. Lesley Flynt
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Correspondence to Lesley Flynt .

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Editors and Affiliations

  1. Department of Nuclear Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Kalevi Kairemo

  2. Department of Nuclear Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Homer A. Macapinlac

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Flynt, L. (2020). 18F Sodium Fluoride: Tracer and Technique. In: Kairemo, K., Macapinlac, H.A. (eds) Sodium Fluoride PET/CT in Clinical Use. Clinicians’ Guides to Radionuclide Hybrid Imaging(). Springer, Cham. https://doi.org/10.1007/978-3-030-23577-2_1

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  • DOI: https://doi.org/10.1007/978-3-030-23577-2_1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-23576-5

  • Online ISBN: 978-3-030-23577-2

  • eBook Packages: MedicineMedicine (R0)

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