Abstract
Antimicrobial resistance (AMR) is a slow but inexorable public health threat and a “wicked problem.” The UK Review on Antimicrobial Resistance projected that up to 10 million deaths could be attributable to AMR by 2050, whereas the World Bank estimated that AMR could independently result in global GDP falling by 1.1–3.8% by 2050 if current practices continue. AMR is, undeniably, a considerable global health security issue. In 2016, the United Nations General Assembly addressed the issue of AMR and announced a global commitment to action.
Acquired AMR occurs and spreads rapidly because of the excessive use of antibiotics in humans and food-producing industries, as well as via environmental pollution with antibiotics. Therefore, a One Health framework is necessary to understand the implications of AMR and to evaluate the impact of current and future interventions.
In this chapter, we attempt to improve the awareness and understanding of AMR as a threat to global health security, in the context of a One Health framework. We begin by defining antimicrobials and describing the emergence and transmission of AMR. We then describe the threats posed by AMR to global health security, in the context of healthcare-associated infections, malaria, HIV/AIDS, TB and fungal infections; to food security, in the context of the complex and controversial practice of industrial farming; and to economic security, in the context of the World Bank global GDP and poverty projections for 2050. We then present global initiatives that address the problem of AMR through a One Health lens, followed by future considerations for continued action against AMR and then conclude with a summary of the chapter.
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Abbreviations
- ACT:
-
Artemisinin-based combination therapy
- AIDS:
-
Acquired immune deficiency syndrome
- AMR:
-
Antimicrobial resistance
- ART:
-
Antiretroviral therapy
- BRICS:
-
Brazil, Russian Federation, India, China and South Africa
- CDC:
-
Centers for Disease Control and Prevention
- CRE:
-
Carbapenem-resistant Enterobacteriaceae
- EEA:
-
European economic area
- EU:
-
European Union
- FAO:
-
Food and Agriculture Organization
- FDA:
-
Food and Drug Administration
- GARDP:
-
Global Antibiotic Research and Development Partnership
- GDP:
-
Gross Domestic Product
- GLASS:
-
Global Antimicrobial Resistance Surveillance System
- HAI:
-
Healthcare Associated Infections
- HIV:
-
Human immunodeficiency virus
- IACG:
-
Interagency Coordination Group on Antimicrobial Resistance
- INH:
-
Isonicotinylhydrazide (isoniazid)
- LMIC:
-
Lower-middle-income countires
- MDG:
-
Millennium development goals
- MDR:
-
Multidrug resistance
- MDR-TB:
-
Multidrug-resistant tuberculosis
- MRSA:
-
Methicillin-resistant Staphylococcus aureus
- OIE:
-
World Organisation for Animal Health
- SDG:
-
Sustainable development goals
- SSI:
-
Surgical site infections
- TB:
-
Tuberculosis
- UN:
-
United Nations
- UTI:
-
Urinary tract infections
- VRE:
-
Vancomycin-resistant Enterococcus
- VRSA:
-
Vancomycin-resistant Staphylococcus aureus
- WB:
-
World Bank
- WHA:
-
World Health Assembly
- WHO:
-
World Health Organization
- WHO CIA List:
-
Who list of critically important antimicrobials for human medicine
- XDR-TB:
-
Extensively drug-resistant tuberculosis
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Medina, Mj., Legido-Quigley, H., Hsu, L.Y. (2020). Antimicrobial Resistance in One Health. In: Masys, A.J., Izurieta, R., Reina Ortiz, M. (eds) Global Health Security. Advanced Sciences and Technologies for Security Applications. Springer, Cham. https://doi.org/10.1007/978-3-030-23491-1_10
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