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Stem Cell Transplantation for Autoimmune Diseases and Inflammation pp 139–157Cite as

Secretome of Mesenchymal Stem Cells and its Impact on Chronic Obstructive Pulmonary Disease

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Part of the book series: Stem Cells in Clinical Applications ((SCCA))

Abstract

Chronic obstructive pulmonary disease (COPD) is characterized by irreversible loss of lung function that stem from two mechanisms, inflammation and senescence. Cross talk between these two mechanisms accelerate the development of COPD; thus, targeting these two pathways may offer benefits in the treatment of COPD. Growing evidence has shown mesenchymal stem cells as a promising candidate for the treatment of COPD. Over the years, many studies have been conducted to decipher the therapeutic effect of MSC in COPD and the mechanisms involved, in the hope of utilizing these cells as a new therapeutic strategy for COPD. However, the cell-based therapy using MSC is presented with many obstacles including low engraftment at the site of injury, the risk of microvascular occlusion, unwanted differentiation, and also the risk of malignant transformation. Recently, researchers begin to look at the possibility of using MSC-derived extracellular vesicles as an alternative to MSC. Here we review the effect of MSC and MSC-derived EV in modulating inflammation, and senescence in COPD. We also review current treatment and side effects in COPD, and senolytic drugs, a new therapeutic strategy targeting the senescent cells.

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Authors and Affiliations

  1. Regenerative Medicine Cluster, Advanced Medical and Dental Institute (AMDI), Universiti Sains Malaysia, Penang, Malaysia

    Noridzzaida Ridzuan & Badrul Hisham Yahaya

  2. Stem Cell Biology and Regenerative Medicine Group, School of Pharmacy, University of Reading, Reading, UK

    Darius Widera

Authors
  1. Noridzzaida Ridzuan
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  2. Darius Widera
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  3. Badrul Hisham Yahaya
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Correspondence to Badrul Hisham Yahaya .

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  1. Laboratory of Stem Cell Research and Application, University of Science, VNU-HCM, Stem Cell Institute, University of Science, VNU-HCM, Ho Chi Minh City, Vietnam

    Phuc Van Pham

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Ridzuan, N., Widera, D., Yahaya, B.H. (2019). Secretome of Mesenchymal Stem Cells and its Impact on Chronic Obstructive Pulmonary Disease. In: Pham, P. (eds) Stem Cell Transplantation for Autoimmune Diseases and Inflammation. Stem Cells in Clinical Applications. Springer, Cham. https://doi.org/10.1007/978-3-030-23421-8_8

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