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Central Nervous System Metastases pp 289–299Cite as

Miscellaneous Metastases

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Abstract

While the majority of cancers metastatic to the central nervous system arise from lung, breast, or melanoma primary tumors, approximately 20–30% arise from other primary tumor sites. In particular, renal cell carcinoma, thyroid tumors, GI cancers (colorectal), germ cell tumors, gynecologic neoplasms (uterine and placental), hematopoietic cancers (lymphoma and leukemia), as well as genitourinary cancers (prostate and bladder) can metastasize to the brain. While these individual histologies rarely metastasize to the CNS, together they represent a sizeable and increasing number of patients as they live longer with improving therapy for their systemic disease and with earlier detection of CNS metastasis. In general, each of these metastases is treated with some combination of whole-brain radiation (WBRT), stereotactic radiosurgery (SRS), systemic chemotherapy, intrathecal chemotherapy, or novel agents, such as immunotherapeutics. In this chapter, we will review the evidence for the management of each of these less common metastases to the brain, with a focus also on the emerging treatments and current research in this area.

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Acknowledgment

Disclosures: DP: None.

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  1. Cleveland Clinic Foundation, Cleveland, OH, USA

    Andrew Dhawan & David Peereboom

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  1. Andrew Dhawan
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  2. David Peereboom
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Correspondence to David Peereboom .

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Editors and Affiliations

  1. Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, OH, USA

    Manmeet Ahluwalia

  2. Department of Neurosurgery and Neuro-Oncology, Clairval Hospital Center, Ramsay-Générale de Santé, Marseille, France, Neurophysiopathology Institute, Aix-Marseille Université, Marseille, France

    Philippe Metellus

  3. Department of Neuro-Oncology, University and City of Health and Science Hospital, Turin, Italy

    Riccardo Soffietti

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Dhawan, A., Peereboom, D. (2020). Miscellaneous Metastases. In: Ahluwalia, M., Metellus, P., Soffietti, R. (eds) Central Nervous System Metastases. Springer, Cham. https://doi.org/10.1007/978-3-030-23417-1_23

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  • DOI: https://doi.org/10.1007/978-3-030-23417-1_23

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