Abstract
Amyotrophic lateral sclerosis (ALS) is a progressive, paralytic disease that affects both upper (brain) and lower (spine and brainstem) motor neurons. While classic ALS is thought to largely spare bladder, bowel, and sphincter function, symptoms can be heterogeneous and phenotypic variants along the motor neuron disease spectrum such as primary lateral sclerosis (PLS) may have more significant lower urinary tract symptoms. Urinary symptoms have been reported in up to 44% of those affected and urinary urgency was the most common symptom. Neurogenic detrusor over activity and detrusor sphincter dyssynergia are common and are associated to storage and voiding symptoms. The urologic care of patients with motor neuron disorders requires a thoughtful and comprehensive approach as these patients may have contraindications to traditional non-invasive medical therapy and may also have significant perioperative risk factors.
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Lane, G., Romo, P.B. (2020). Amyotrophic Lateral Sclerosis and Motor Neuron Disorders. In: Stoffel, J.T., Dray, E.V. (eds) Urological Care for Patients with Progressive Neurological Conditions. Springer, Cham. https://doi.org/10.1007/978-3-030-23277-1_14
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DOI: https://doi.org/10.1007/978-3-030-23277-1_14
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