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Heat Shock Protein 90 in Severe Trauma

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Book cover Heat Shock Protein 90 in Human Diseases and Disorders

Part of the book series: Heat Shock Proteins ((HESP,volume 19))

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Abstract

Trauma is an important health problem in modern society. Its serious consequences, such as sepsis and multiple organ dysfunction, are the leading causes of high morbidity and mortality. The heat shock proteins (HSP) increase rapidly under a wide variety of stressful conditions to protect cell from damage. Overexpression of HSP is associated with apoptosis inhibition, inflammatory response and immunomodulation in severe trauma. Therefore, the changes in expression levels of various heat shock proteins or the differences in genetic background will affect the processes and medical outcomes of patients or animal models of diseases. Most importantly, HSP play differential and complex roles in the regulation of inflammation and immunity at different pathological stages and locations after severe trauma. In addition to the traditional therapeutic methods, strategies by the control of HSP expression and consideration of individual genetic background will pave the way for the better treatment and prediction of serious complications caused by severe trauma. In this chapter, the recent progresses of HSP in severe trauma and its complications and the possibilities of HSP as therapeutic targets will be discussed.

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Abbreviations

DIC:

Disseminated intravascular coagulation

HSP:

Heat shock proteins

IL:

Interleukin

MODS:

Multiple organ dysfunction syndrome

References

  • Ackermann M, Reuter M, Flohe S, Bahrami S, Redl H, Schade FU (2001) Cytokine synthesis in the liver of endotoxin-tolerant and normal rats during hemorrhagic shock. J Endotoxin Res 7:105–112

    Article  CAS  PubMed  Google Scholar 

  • Ambade A, Catalano D, Lim A, Mandrekar P (2012) Inhibition of heat shock protein (molecular weight 90 kDa) attenuates proinflammatory cytokines and prevents lipopolysaccharide-induced liver injury in mice. Hepatology 55:1585–1595

    Article  CAS  PubMed  Google Scholar 

  • Antonov A, Snead C, Gorshkov B, Antonova GN, Verin AD, Catravas JD (2008) Heat shock protein 90 inhibitors protect and restore pulmonary endothelial barrier function. Am J Respir Cell Mol Biol 39:551–559

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Arya R, Mallik M, Lakhotia SC (2007) Heat shock genes – integrating cell survival and death. J Biosci 32:595–610

    Article  CAS  PubMed  Google Scholar 

  • Bedet A, Razazi K, Boissier F, Surenaud M, Hue S, Giraudier S, Brun-Buisson C, Mekontso Dessap A (2018) Mechanisms of thrombocytopenia during septic shock: a multiplex cluster analysis of endogenous sepsis mediators. Shock 49:641–648

    Article  PubMed  Google Scholar 

  • Beere HM (2005) Death versus survival: functional interaction between the apoptotic and stress-inducible heat shock protein pathways. J Clin Invest 115:2633–2639

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Calderwood SK, Mambula SS, Gray PJ Jr, Theriault JR (2007) Extracellular heat shock proteins in cell signaling. FEBS Lett 581:3689–3694

    Article  CAS  PubMed  Google Scholar 

  • Chang CK, Chang CP, Chiu WT, Lin MT (2006) Prevention and repair of circulatory shock and cerebral ischemia/injury by various agents in experimental heatstroke. Curr Med Chem 13:3145–3154

    Article  CAS  PubMed  Google Scholar 

  • Chatterjee A, Dimitropoulou C, Drakopanayiotakis F, Antonova G, Snead C, Cannon J, Venema RC, Catravas JD (2007a) Heat shock protein 90 inhibitors prolong survival, attenuate inflammation, and reduce lung injury in murine sepsis. Am J Respir Crit Care Med 176:667–675

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chatterjee S, Premachandran S, Shukla J, Poduval TB (2007b) Synergistic therapeutic potential of dexamethasone and L-arginine in lipopolysaccharide-induced septic shock. J Surg Res 140:99–108

    Article  CAS  PubMed  Google Scholar 

  • Chatterjee A, Snead C, Yetik-Anacak G, Antonova G, Zeng J, Catravas JD (2008) Heat shock protein 90 inhibitors attenuate LPS-induced endothelial hyperpermeability. Am J Physiol Lung Cell Mol Physiol 294:L755–L763

    Article  CAS  PubMed  Google Scholar 

  • Chebotareva N, Bobkova I, Shilov E (2017) Heat shock proteins and kidney disease: perspectives of HSP therapy. Cell Stress Chaperones 22:319–343

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chen G, Cao P, Goeddel DV (2002) TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90. Mol Cell 9:401–410

    Article  CAS  PubMed  Google Scholar 

  • Chen Y, Voegeli TS, Liu PP, Noble EG, Currie RW (2007) Heat shock paradox and a new role of heat shock proteins and their receptors as anti-inflammation targets. Inflamm Allergy Drug Targets 6:91–100

    Article  CAS  PubMed  Google Scholar 

  • Echeverria PC, Mazaira G, Erlejman A, Gomez-Sanchez C, Piwien Pilipuk G, Galigniana MD (2009) Nuclear import of the glucocorticoid receptor-hsp90 complex through the nuclear pore complex is mediated by its interaction with Nup62 and importin beta. Mol Cell Biol 29:4788–4797

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Egorina EM, Sovershaev MA, Kondratiev TV, Olsen JO, Tveita T, Osterud B (2006) Induction of monocytic tissue factor expression after rewarming from hypothermia in vivo is counteracted by heat shock in c-Jun-dependent manner. Arterioscler Thromb Vasc Biol 26:2401–2406

    Article  CAS  PubMed  Google Scholar 

  • Fitrolaki MD, Dimitriou H, Venihaki M, Katrinaki M, Ilia S, Briassoulis G (2016) Increased extracellular heat shock protein 90alpha in severe sepsis and SIRS associated with multiple organ failure and related to acute inflammatory-metabolic stress response in children. Medicine (Baltimore) 95:e4651

    Article  CAS  Google Scholar 

  • Flohe SB, Bangen JM, Flohe S, Agrawal H, Bergmann K, Schade FU (2007) Origin of immunomodulation after soft tissue trauma: potential involvement of extracellular heat-shock proteins. Shock 27:494–502

    Article  CAS  PubMed  Google Scholar 

  • Gabai VL, Mabuchi K, Mosser DD, Sherman MY (2002) Hsp72 and stress kinase c-jun N-terminal kinase regulate the bid-dependent pathway in tumor necrosis factor-induced apoptosis. Mol Cell Biol 22:3415–3424

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gu Y, Chen J, Wang T, Zhou C, Liu Z, Ma L (2016) Hsp70 inducer, 17-allylamino-demethoxygeldanamycin, provides neuroprotection via anti-inflammatory effects in a rat model of traumatic brain injury. Exp Ther Med 12:3767–3772

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Guisasola MC, Ortiz A, Chana F, Alonso B, Vaquero J (2015) Early inflammatory response in polytraumatized patients: cytokines and heat shock proteins. A pilot study. Orthop Traumatol Surg Res 101:607–611

    Article  CAS  PubMed  Google Scholar 

  • Guisasola MC, Alonso B, Bravo B, Vaquero J, Chana F (2018) An overview of cytokines and heat shock response in polytraumatized patients. Cell Stress Chaperones 23:483–489

    Article  CAS  PubMed  Google Scholar 

  • Heydari AR, Takahashi R, Gutsmann A, You S, Richardson A (1994) Hsp70 and aging. Experientia 50:1092–1098

    Article  CAS  PubMed  Google Scholar 

  • Jabandziev P, Smerek M, Michalek J, Fedora M, Kosinova L, Hubacek JA, Michalek J (2014) Multiple gene-to-gene interactions in children with sepsis: a combination of five gene variants predicts outcome of life-threatening sepsis. Crit Care 18:R1

    Article  PubMed  PubMed Central  Google Scholar 

  • Kardynska M, Paszek A, Smieja J, Spiller D, Widlak W, White MRH, Paszek P, Kimmel M (2018) Quantitative analysis reveals crosstalk mechanisms of heat shock-induced attenuation of NF-kappaB signaling at the single cell level. PLoS Comput Biol 14:e1006130

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kim K, Kim W, Rhee JE, Jo YH, Lee JH, Kim KS, Kwon WY, Suh GJ, Lee CC, Singer AJ (2010) Induced hypothermia attenuates the acute lung injury in hemorrhagic shock. J Trauma 68:373–381

    Article  PubMed  Google Scholar 

  • Leijte GP, Custers H, Gerretsen J, Heijne A, Roth J, Vogl T, Scheffer GJ, Pickkers P, Kox M (2018) Increased plasma levels of danger-associated molecular patterns are associated with immune suppression and postoperative infections in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Front Immunol 9:663

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Li CY, Lee JS, Ko YG, Kim JI, Seo JS (2000) Heat shock protein 70 inhibits apoptosis downstream of cytochrome c release and upstream of caspase-3 activation. J Biol Chem 275:25665–25671

    Article  CAS  PubMed  Google Scholar 

  • Li X, Yu Y, Gorshkov B, Haigh S, Bordan Z, Weintraub D, Rudic RD, Chakraborty T, Barman SA, Verin AD, Su Y, Lucas R, Stepp DW, Chen F, Fulton DJR (2018) Hsp70 suppresses mitochondrial reactive oxygen species and preserves pulmonary microvascular barrier integrity following exposure to bacterial toxins. Front Immunol 9:1309

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Lin KC, Lin HJ, Chang CP, Lin MT (2015) Decreasing or increasing heat shock protein 72 exacerbates or attenuates heat-induced cell death, respectively, in rat hypothalamic cells. FEBS Open Biol 5:724–730

    Article  CAS  Google Scholar 

  • MacLean MJ, Llordella MM, Bot N, Picard D (2005) A yeast-based assay reveals a functional defect of the Q488H polymorphism in human Hsp90alpha. Biochem Biophys Res Commun 337:133–137

    Article  CAS  PubMed  Google Scholar 

  • Madach K, Molvarec A, Rigo J Jr, Nagy B, Penzes I, Karadi I, Prohaszka Z (2008) Elevated serum 70 kDa heat shock protein level reflects tissue damage and disease severity in the syndrome of hemolysis, elevated liver enzymes, and low platelet count. Eur J Obstet Gynecol Reprod Biol 139:133–138

    Article  CAS  PubMed  Google Scholar 

  • Mazloomi E, Jazani NH, Sohrabpour M, Ilkhanizadeh B, Shahabi S (2011) Synergistic effects of glutamine and ciprofloxacin in reduction of Pseudomonas aeruginosa-induced septic shock severity. Int Immunopharmacol 11:2214–2219

    Article  CAS  PubMed  Google Scholar 

  • McConnell KW, Fox AC, Clark AT, Chang NY, Dominguez JA, Farris AB, Buchman TG, Hunt CR, Coopersmith CM (2011) The role of heat shock protein 70 in mediating age-dependent mortality in sepsis. J Immunol 186:3718–3725

    Article  CAS  PubMed  Google Scholar 

  • Nathan DF, Lindquist S (1995) Mutational analysis of Hsp90 function: interactions with a steroid receptor and a protein kinase. Mol Cell Biol 15:3917–3925

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • O’Neill S, Humphries D, Tse G, Marson LP, Dhaliwal K, Hughes J, Ross JA, Wigmore SJ, Harrison EM (2015) Heat shock protein 90 inhibition abrogates TLR4-mediated NF-kappaB activity and reduces renal ischemia-reperfusion injury. Sci Rep 5:12958

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Ondruschka B, Rosinsky F, Trauer H, Schneider E, Dressler J, Franke H (2018) Drug- and/or trauma-induced hyperthermia? Characterization of HSP70 and myoglobin expression. PLoS One 13:e0194442

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Papadopoulos P, Pistiki A, Theodorakopoulou M, Christodoulopoulou T, Damoraki G, Goukos D, Briassouli E, Dimopoulou I, Armaganidis A, Nanas S, Briassoulis G, Tsiodras S (2017) Immunoparalysis: clinical and immunological associations in SIRS and severe sepsis patients. Cytokine 92:83–92

    Article  CAS  PubMed  Google Scholar 

  • Passarino G, Cavalleri GL, Stecconi R, Franceschi C, Altomare K, Dato S, Greco V, Luca Cavalli Sforza L, Underhill PA, de Benedictis G (2003) Molecular variation of human HSP90alpha and HSP90beta genes in Caucasians. Hum Mutat 21:554–555

    Article  PubMed  CAS  Google Scholar 

  • Radons J, Multhoff G (2005) Immunostimulatory functions of membrane-bound and exported heat shock protein 70. Exerc Immunol Rev 11:17–33

    PubMed  Google Scholar 

  • Ramakrishna K, Pugazhendhi S, Kabeerdoss J, Peter JV (2014) Association between heat shock protein 70 gene polymorphisms and clinical outcomes in intensive care unit patients with sepsis. Indian J Crit Care Med 18:205–211

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Ranek MJ, Stachowski MJ, Kirk JA, Willis MS (2018) The role of heat shock proteins and co-chaperones in heart failure. Philos Trans R Soc Lond Ser B Biol Sci 373:20160530

    Google Scholar 

  • Rashed M, Bayraktar E, Helal G, Abd-Ellah MF, Amero P, Chavez-Reyes A, Rodriguez-Aguayo C (2017) Exosomes: from garbage bins to promising therapeutic targets. Int J Mol Sci 18:538

    Google Scholar 

  • Rozhkova E, Yurinskaya M, Zatsepina O, Garbuz D, Karpov V, Surkov S, Murashev A, Ostrov V, Margulis B, Evgen’ev M, Vinokurov M (2010) Exogenous mammalian extracellular HSP70 reduces endotoxin manifestations at the cellular and organism levels. Ann N Y Acad Sci 1197:94–107

    Article  CAS  PubMed  Google Scholar 

  • Saleh A, Srinivasula SM, Balkir L, Robbins PD, Alnemri ES (2000) Negative regulation of the Apaf-1 apoptosome by Hsp70. Nat Cell Biol 2:476–483

    Article  CAS  PubMed  Google Scholar 

  • Santos-Junior VA, Lollo PCB, Cantero MA, Moura CS, Amaya-Farfan J, Morato PN (2018) Heat shock proteins: protection and potential biomarkers for ischemic injury of cardiomyocytes after surgery. Braz J Cardiovasc Surg 33:291–302

    Article  PubMed  PubMed Central  Google Scholar 

  • Schroder O, Schulte KM, Ostermann P, Roher HD, Ekkernkamp A, Laun RA (2003) Heat shock protein 70 genotypes HSPA1B and HSPA1L influence cytokine concentrations and interfere with outcome after major injury. Crit Care Med 31:73–79

    Article  PubMed  Google Scholar 

  • Schroeder S, Lindemann C, Hoeft A, Putensen C, Decker D, von Ruecker AA, Stuber F (1999) Impaired inducibility of heat shock protein 70 in peripheral blood lymphocytes of patients with severe sepsis. Crit Care Med 27:1080–1084

    Article  CAS  PubMed  Google Scholar 

  • Shen HY, Zhao Y, Chen XY, Xiong RP, Lu JL, Chen JF, Chen LY, Zhou YG (2010) Differential alteration of heat shock protein 90 in mice modifies glucocorticoid receptor function and susceptibility to trauma. J Neurotrauma 27:373–381

    Article  PubMed  Google Scholar 

  • Shen HH, Huang SY, Cheng PY, Chu YJ, Chen SY, Lam KK, Lee YM (2017) Involvement of HSP70 and HO-1 in the protective effects of raloxifene on multiple organ dysfunction syndrome by endotoxemia in ovariectomized rats. Menopause 24:959–969

    Article  PubMed  Google Scholar 

  • Singh R, Kolvraa S, Bross P, Jensen UB, Gregersen N, Tan Q, Knudsen C, Rattan SI (2006) Reduced heat shock response in human mononuclear cells during aging and its association with polymorphisms in HSP70 genes. Cell Stress Chaperones 11:208–215

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Spanaki AM, Tavladaki T, Dimitriou H, Kozlov AV, Duvigneau JC, Meleti E, Weidinger A, Papakonstantinou E, Briassoulis G (2018) Longitudinal profiles of metabolism and bioenergetics associated with innate immune hormonal inflammatory responses and amino-acid kinetics in severe Sepsis and systemic inflammatory response syndrome in children. JPEN J Parenter Enteral Nutr 42:1061–1074

    Article  CAS  PubMed  Google Scholar 

  • Su F, Nguyen ND, Wang Z, Cai Y, Rogiers P, Vincent JL (2005) Fever control in septic shock: beneficial or harmful? Shock 23:516–520

    PubMed  Google Scholar 

  • Sucker C, Zacharowski K, Thielmann M, Hartmann M (2007) Heat shock inhibits lipopolysaccharide-induced tissue factor activity in human whole blood. Thromb J 5:13

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Sucker C, Paniczek S, Scharf RE, Litmathe J, Hartmann M (2013) Rotation thromboelastography for the detection and characterization of lipoteichoid acid-induced activation of haemostasis in an in vitro sepsis model. Perfusion 28:146–151

    Article  CAS  PubMed  Google Scholar 

  • Takahashi T, Suzuki T, Yamasaki A, Tsukiji T, Hirakawa M, Akagi R (1999) Heat shock response in a rat model of septic multiple organ dysfunction syndrome. Nihon Yakurigaku Zasshi 114:295–302

    Article  CAS  PubMed  Google Scholar 

  • Tunctan B, Korkmaz B, Sari AN, Kacan M, Unsal D, Serin MS, Buharalioglu CK, Sahan-Firat S, Cuez T, Schunck WH, Manthati VL, Falck JR, Malik KU (2013) Contribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1, and gp91(phox) to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia, and inflammation in a rat model of septic shock. Nitric Oxide 33:18–41

    Article  CAS  PubMed  Google Scholar 

  • van Eden W, van der Zee R, Prakken B (2005) Heat-shock proteins induce T-cell regulation of chronic inflammation. Nat Rev Immunol 5:318–330

    Article  PubMed  CAS  Google Scholar 

  • Van Molle W, Wielockx B, Mahieu T, Takada M, Taniguchi T, Sekikawa K, Libert C (2002) HSP70 protects against TNF-induced lethal inflammatory shock. Immunity 16:685–695

    Article  PubMed  Google Scholar 

  • Vardas K, Apostolou K, Briassouli E, Goukos D, Psarra K, Botoula E, Tsagarakis S, Magira E, Routsi C, Nanas S, Briassoulis G (2014) Early response roles for prolactin cortisol and circulating and cellular levels of heat shock proteins 72 and 90alpha in severe sepsis and SIRS. Biomed Res Int 2014:803561

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Vardas K, Ilia S, Sertedaki A, Charmandari E, Briassouli E, Goukos D, Apostolou K, Psarra K, Botoula E, Tsagarakis S, Magira E, Routsi C, Stratakis CA, Nanas S, Briassoulis G (2017) Increased glucocorticoid receptor expression in sepsis is related to heat shock proteins, cytokines, and cortisol and is associated with increased mortality. Intensive Care Med Exp 5:10

    Article  PubMed  PubMed Central  Google Scholar 

  • Villar J, Ribeiro SP, Mullen JB, Kuliszewski M, Post M, Slutsky AS (1994) Induction of the heat shock response reduces mortality rate and organ damage in a sepsis-induced acute lung injury model. Crit Care Med 22:914–921

    Article  CAS  PubMed  Google Scholar 

  • Vinokurov M, Ostrov V, Yurinskaya M, Garbuz D, Murashev A, Antonova O, Evgen’ev M (2012) Recombinant human Hsp70 protects against lipoteichoic acid-induced inflammation manifestations at the cellular and organismal levels. Cell Stress Chaperones 17:89–101

    Article  CAS  PubMed  Google Scholar 

  • Wang Q, Hasselgren PO (2002) Heat shock response reduces intestinal permeability in septic mice: potential role of interleukin-10. Am J Physiol Regul Integr Comp Physiol 282:R669–R676

    Article  CAS  PubMed  Google Scholar 

  • Wang YL, Lam KK, Cheng PY, Lee YM (2015) Celastrol prevents circulatory failure via induction of heme oxygenase-1 and heat shock protein 70 in endotoxemic rats. J Ethnopharmacol 162:168–175

    Article  CAS  PubMed  Google Scholar 

  • Wang YL, Shen HH, Cheng PY, Chu YJ, Hwang HR, Lam KK, Lee YM (2016) 17-DMAG, an HSP90 inhibitor, ameliorates multiple organ dysfunction syndrome via induction of HSP70 in endotoxemic rats. PLoS One 11:e0155583

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Wang Y, Sedlacek AL, Pawaria S, Xu H, Scott MJ, Binder RJ (2018) Cutting edge: the heat shock protein gp96 activates inflammasome-signaling platforms in APCs. J Immunol 201:2209–2214

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhao Y, Shen HY, Chen XY, Xiong RP, Li P, Liu P, Yang N, Zhou YG (2010) Genetic variations of heat shock protein 84 in mice mediate cellular glucocorticoid response. Cell Physiol Biochem 25:359–366

    Article  CAS  PubMed  Google Scholar 

  • Zhao Y, Tao L, Jiang D, Chen X, Li P, Ning Y, Xiong R, Liu P, Peng Y, Zhou YG (2013) The -144C/A polymorphism in the promoter of HSP90beta is associated with multiple organ dysfunction scores. PLoS One 8:e58646

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhao Y, Xiong RP, Chen X, Li P, Ning YL, Yang N, Peng Y, Jiang YL, Zhou YG (2018) Hsp90 regulation affects the treatment of glucocorticoid for pancreatitis-induced lung injury. Mol Cell Biochem 440:189–197

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

The authors thank the State Key Laboratory of Trauma, Burn and Combined Injury. This work was supported in part by the National Natural Science Foundation of China [Grant 30470988].

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Authors and Affiliations

  1. Molecular Biology Center, The State Key Laboratory of Trauma, Burn and Combined Injury, Research Institute of Surgery and Daping Hospital, Third Military Medical University, Chongqing, China

    Yan Zhao & Yuan-Guo Zhou

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  1. Yan Zhao
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  2. Yuan-Guo Zhou
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Correspondence to Yuan-Guo Zhou .

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Editors and Affiliations

  1. Department of Medicine and Director, Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer Center, University of Toledo, College of Medicine and Life Sciences, Toledo, OH, USA

    Alexzander A. A. Asea

  2. Department of Experimental Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA

    Punit Kaur

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Zhao, Y., Zhou, YG. (2019). Heat Shock Protein 90 in Severe Trauma. In: Asea, A., Kaur, P. (eds) Heat Shock Protein 90 in Human Diseases and Disorders. Heat Shock Proteins, vol 19. Springer, Cham. https://doi.org/10.1007/978-3-030-23158-3_24

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