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Heat Shock Protein 60 in Human Diseases and Disorders pp 117–134Cite as

Hsp60 in Cancer Immunity: Biological Basis, Diagnostic Potential and Therapeutic Opportunities

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Part of the book series: Heat Shock Proteins ((HESP,volume 18))

Abstract

Hsp60 is involved in tumor immune mechanisms leading to recognition of transformed cells and inhibition of growth of neoplastic tissue. As tumors grow, Hsp60 participates in disease progression through its involvement in immunoescape. In this chapter, the interactions between Hsp60 and the tumor microenvironment are discussed as they offer key elements to illustrate the context-dependent functions of Hsp60 in tumor immunomodulation. Next, the applicability of Hsp60 as a diagnostic, prognostic, and marker for therapy response is discussed. Finally, the prospect of targeting Hsp60 and its immunomodulatory effects in tumors is explored. A critical component of self- and nonself-recognition, Hsp60 has value as a tumor marker and therapeutic agent. Study of its context-dependent immune functions offer the prospect of delivering better diagnostic and personalized therapeutic approaches.

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Abbreviations

CTL:

Cytotoxic T lymphocytes

HSP:

Heat shock proteins

IHC:

Immunohistochemistry

MC:

Myrtucommulone A

MDSC:

Myeloid-derived suppressor cells

NK:

Natural killer

TAA:

Tumor-associated antigens

TAM:

Tumor-associated macrophages

TME:

Tumor microenvironment

Treg:

Regulatory T cells

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Acknowledgements

The author thanks Drs. Venkat Mannam, Ingrid Espinoza, and Amit Reddy for valuable discussions and critical reading of the manuscript. This work was supported in part by Grant DOD PC094680 and PCF Creativity Award.

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Authors and Affiliations

  1. Department of Pathology, University of Mississippi Center for Clinical and Translational Science, University of Mississippi Medical Center, Jackson, MS, USA

    Christian R. Gomez

  2. Department of Radiation Oncology, University of Mississippi Center for Clinical and Translational Science, University of Mississippi Medical Center, Jackson, MS, USA

    Christian R. Gomez

  3. Translational and Clinical Research Unit, University of Mississippi Center for Clinical and Translational Science, University of Mississippi Medical Center, Jackson, MS, USA

    Christian R. Gomez

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  1. Christian R. Gomez
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Correspondence to Christian R. Gomez .

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Editors and Affiliations

  1. Department of Medicine and Director, Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer Center, University of Toledo, College of Medicine and Life Sciences, Toledo, OH, USA

    Alexzander A. A. Asea

  2. Department of Experimental Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA

    Punit Kaur

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Gomez, C.R. (2019). Hsp60 in Cancer Immunity: Biological Basis, Diagnostic Potential and Therapeutic Opportunities. In: Asea, A., Kaur, P. (eds) Heat Shock Protein 60 in Human Diseases and Disorders. Heat Shock Proteins, vol 18. Springer, Cham. https://doi.org/10.1007/978-3-030-23154-5_9

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