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Heat Shock Protein 60 in Human Diseases and Disorders pp 107–116Cite as

Exosomal Hsp60: A Tumor Biomarker?

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Part of the book series: Heat Shock Proteins ((HESP,volume 18))

Abstract

Exosomes (EXs) are extracellular vesicles containing proteins, DNA, mRNA, non-coding RNAs, such as miRNAs, and lipid. The EXs can be easily isolated from different biological fluids and their content is considered a potential biomarker in various diseases, such as cancer. EXs play an important role in intercellular communication, permitting cells to exchange proteins, lipids, and genetic material in normal and pathological conditions. New data have shown that tumor cells-derived EXs contribute to cancer progression through the modulation of tumor microenvironment. Heat shock proteins 60 kDa (Hsp60) is classically considered mitochondrial proteins with different biological roles. In recent years, many studies have focused on the extracellular roles played by Hsp60 that appear to be involved in cancer development and immune system stimulation. Hsp60 is localized on the surface of EXs, secreted by cells and could be a key player in intercellular cross-talk during the course of different diseases. Therefore, exosomal Hsp60 has a great potential for clinical applications, including its use as biomarker for diagnostics, assessing prognosis, and monitoring disease progression and response to treatment, particularly in cancer.

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Abbreviations

ESCRT:

endosomal sorting complex

EVs:

extracellular vesicles

EXs:

exosomes

Hsp:

heat shock proteins

Hsp60:

heat shock protein 60 kDa

ILVs:

intraluminal vesicles

MVBs:

multivesicular bodies

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Acknowledgements

C.C. and G.A. C.C.B. were partially supported by UniPA.

Author information

Authors and Affiliations

  1. Department of Therapeutic Research and Medicines Evaluation, National Institute of Health, Rome, Italy

    Stefano Fais & Mariantonia Logozzi

  2. Euro-Mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy

    Stefano Fais & Claudia Campanella

  3. Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), Section of Human Anatomy, University of Palermo, Palermo, Italy

    Giusi Alberti & Claudia Campanella

Authors
  1. Stefano Fais
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  2. Mariantonia Logozzi
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  3. Giusi Alberti
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  4. Claudia Campanella
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Corresponding author

Correspondence to Claudia Campanella .

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Editors and Affiliations

  1. Department of Medicine and Director, Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer Center, University of Toledo, College of Medicine and Life Sciences, Toledo, OH, USA

    Alexzander A. A. Asea

  2. Department of Experimental Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA

    Punit Kaur

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Fais, S., Logozzi, M., Alberti, G., Campanella, C. (2019). Exosomal Hsp60: A Tumor Biomarker?. In: Asea, A., Kaur, P. (eds) Heat Shock Protein 60 in Human Diseases and Disorders. Heat Shock Proteins, vol 18. Springer, Cham. https://doi.org/10.1007/978-3-030-23154-5_8

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