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Role of HSP60 in Steroidogenesis and Reproduction

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Heat Shock Protein 60 in Human Diseases and Disorders

Part of the book series: Heat Shock Proteins ((HESP,volume 18))

Abstract

Heat shock proteins (HSP) play an important role in cellular homeostasis; however, they have recently been involved also in diverse relevant biological processes, like cellular proliferation and differentiation. It has been suggested that they could play an important role in some pathologies, such as cancer and atherosclerosis, making them an attractive therapeutic target. The high degree of HSP’ conservation along evolution suggests that these proteins provide intrinsic defense mechanisms to cells against stress conditions. This chapter provides general information on heat shock proteins, as well as on their role in some pathophysiological processes related to reproduction. It also approaches the association of HSP with hormones and their participation in steroidogenesis, because hormones are critical mediators in regulating development, reproduction, and homeostasis in general. This chapter emphasizes the Hsp60, which has been suggested to have a relevant role in steroid hormones synthesis; besides, this protein is located in mitochondrial contact sites favoring progesterone synthesis in the human placenta.

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Abbreviations

3β-HSD:

3 beta hydroxy steroid dehydrogenase

ACTH:

adrenocorticotropic hormone

AKT:

protein kinase B (PKB, Akt)

APAF-1:

apoptotic protease activating factor 1

APG-1 protein:

ATP and peptide-binding protein in germ cells

BAD:

Bcl2-associated agonist of cell death (Bcl2-L-8)

Bax:

apoptosis regulator (Bcl2-L-4)

ERK:

extracellular signal-regulated kinases

FSH:

follicle-stimulating hormone

HDL:

high-density lipoproteins

HspB1:

heat shock protein beta-1

LH:

luteinizing hormone

LPS:

lipopolysaccharide

MLN64:

metastatic lymph node 64 protein (STARD3)

P450scc:

cholesterol side-chain cleavage enzyme

PI3K:

phosphoinositide 3-kinase

PKA:

protein kinase A

RAF kinase:

rapidly accelerated fibrosarcoma kinase

SMAC:

second mitochondria-derived activator of caspases

StAR:

steroidogenic acute protein (STARD1)

TIM:

translocase of the inner membrane

TNF:

tumor necrosis factor

TOM:

translocase of the outer membrane

TSPO:

translocator protein

VDAC:

voltage-dependent anion channel

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Acknowledgements

This work was partially supported by Grants IN211912, IN211715 and IN215518 (FM), IN222617 (OFH) from Dirección General de Apoyo al Personal Académico (UNAM), and 168025 (FM) from Consejo Nacional de Ciencia y Tecnología, México.

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  1. Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico

    Sofia Olvera-Sanchez, Jessica Monreal-Flores, Oscar Flores-Herrera & Federico Martinez

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  1. Sofia Olvera-Sanchez
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  2. Jessica Monreal-Flores
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  3. Oscar Flores-Herrera
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  4. Federico Martinez
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Correspondence to Federico Martinez .

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  1. Department of Medicine and Director, Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer Center, University of Toledo, College of Medicine and Life Sciences, Toledo, OH, USA

    Alexzander A. A. Asea

  2. Department of Experimental Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA

    Punit Kaur

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Olvera-Sanchez, S., Monreal-Flores, J., Flores-Herrera, O., Martinez, F. (2019). Role of HSP60 in Steroidogenesis and Reproduction. In: Asea, A., Kaur, P. (eds) Heat Shock Protein 60 in Human Diseases and Disorders. Heat Shock Proteins, vol 18. Springer, Cham. https://doi.org/10.1007/978-3-030-23154-5_20

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