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Heat Shock Protein 60 Regulation of Skeletal Tissue Integrity

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Heat Shock Protein 60 in Human Diseases and Disorders

Part of the book series: Heat Shock Proteins ((HESP,volume 18))

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Abstract

Osteoporosis and osteoarthritis are the most prevalent degenerative skeletal diseases in the elderly. Deregulated osteoblast and chondrocyte behavior are prominent cellular features of these disorders. Organelle dysfunction disturbs cell survival and differentiation capacity, accelerating bone mass and articular cartilage loss. Heat shock protein 60 (HSP60) is a mitochondrial chaperonin essential to mitochondrial integrity and proteostasis. Its function to skeletal tissue homeostasis and degeneration warrants systemic characterization. Here, we highlight the merging evidence in regard to the involvement of this chaperonin in mitochondrial biogenesis, autophagy, and post-translational modification of bioactive proteins, contributing to tissue homeostasis, deterioration, and tumorigenesis in various physiological and pathological contexts. This article sheds a new light on the beneficial actions of HSP60 to osteoblast autophagy that protects bone tissue against osteoporosis development. We also offer a productive insight into how this chaperone protein sustains chondrocyte function to facilitate cartilage development and slow down osteoarthritis progression.

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Abbreviations

μCT:

microcomputed tomography

Acetyl CoA:

acetyl coenzyme A

ADP:

adenosine diphosphate

AMPK:

AMP-activated protein kinase

Atg:

autophagy related proteins

ATP:

adenosine triphosphate

Bax:

BCL2 associated X apoptosis regulator

BNIP3:

BCL2 interacting protein 3

DKK-1:

dickkopf-1

ERK:

extracellular regulated MAP kinase

FOXO:

forkhead box subgroup O

HDAC1:

histone deacetylase 1

HSP60:

heat shock protein 60

HSPd1:

heat shock protein family D member 1

IGF-1:

insulin-like growth factor-1

IL-1β:

interleukin-1β

LC3:

microtubule associates protein 1 light chain 3 alpha

MMP:

matrix metalloproteinases

MSC:

mesenchymal stem cells

mtDNA:

mitochondrial DNA

mTOR:

mechanistic target of rapamycin kinase

NAD+:

nicotinamide adenine dinucleotide

NRF:

nuclear respiratory factor

OA:

osteoarthritis

O-GlcNAc:

O-linked N-acetylaglucosamine

PGC-1α:

peroxisome proliferator-activated receptor γ coactivator-1α

PGK:

phosphoglycerates kinase

PINK1:

PTEN induced kinase 1

PKA:

protein kinase A

PP2A:

serine-threonine protein phosphatase 2A

PTM:

post-translational modification reactions

RANKL:

receptor activator nuclear factor-κ ligand

REDD1:

DNA damage inducible transcript 4

RPTOR:

regulator-associated protein of mTOR complex 1

SOX9:

SRY-box 9

TCA:

tricarboxylic acid

SUMO:

small ubiquitin like modifier proteins

TFAM:

mitochondrial transcription factor A

TGF-β1:

transforming growth factor-β1

TNF-α:

tumor necrosis factor-α

ULK1:

unc-51 like autophagy activating kinase

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Acknowledgements

This work was in part supported by grants [NHRI-EX107-10736SI] from the National Health Research Institute, [MOST107-2314-B-182A-038MY3; MOST107-2314-B-182A-012-MY2] from Ministry of Science and Technology, and [CMRPG8H0211-3; CLRPG8G0701-3] from Chang Gung Memorial Hospital, Taiwan.

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  1. Authors Feng-Sheng Wang and Wei-Shiung Lian are equally contributed to this chapter.

Authors and Affiliations

  1. Core Laboratory for Phenomics & Diagnostics, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan

    Feng-Sheng Wang, Wei-Shiung Lian, Chung-Wen Kuo & Yu-Shan Chen

  2. Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan

    Feng-Sheng Wang

  3. Department of Nursing, Fooyin University, Kaohsiung, Taiwan

    Pei-Rong Chang

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Correspondence to Feng-Sheng Wang .

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Editors and Affiliations

  1. Department of Medicine and Director, Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer Center, University of Toledo, College of Medicine and Life Sciences, Toledo, OH, USA

    Alexzander A. A. Asea

  2. Department of Experimental Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA

    Punit Kaur

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Wang, FS., Lian, WS., Kuo, CW., Chen, YS., Chang, PR. (2019). Heat Shock Protein 60 Regulation of Skeletal Tissue Integrity. In: Asea, A., Kaur, P. (eds) Heat Shock Protein 60 in Human Diseases and Disorders. Heat Shock Proteins, vol 18. Springer, Cham. https://doi.org/10.1007/978-3-030-23154-5_19

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