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Anti-human Hsp60 Autoantibodies in Autoimmune and Inflammatory Rheumatic Diseases

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Heat Shock Protein 60 in Human Diseases and Disorders

Part of the book series: Heat Shock Proteins ((HESP,volume 18))

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Abstract

Autoantibodies against human heat shock protein 60 (Hsp60) have been implicated in the pathogenesis of autoimmune and inflammatory rheumatic diseases (AIRDs), including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), systemic sclerosis, Sjogren’s syndrome and various idiopathic vasculitides. Anti-human Hsp60 autoantibodies can be detected in the sera of patients with AIRDs in various frequencies and levels; therefore, their diagnostic, clinical and pathogenic importance remains enigmatic. Regarding their clinical significance, several studies have implicated them in AIRDs with vascular manifestations, including SLE and primary vasculitides. For other diseases, however, clinical associations have not been comprehensively investigated. Their pathogenetic role is also questionable, although several studies have suggested an apoptotic capacity of anti-Hsp60 autoantibodies on osteoblasts and endothelial cells, linking them with joint inflammation and bone erosion in RA and vascular inflammation in SLE and vasculitides, respectively. In addition, molecular mimicry based on amino acid similarities between human Hsp60 and bacterial Hsp60 or other bacterial antigens has been implicated in the production of cross-reactive autoantibodies in AIRDS, connecting infection with autoimmunity and autoimmune disease. In search of the connection between anti-human Hsp60 autoantibodies and AIRDS, the current chapter reviews research advances in the field and discusses prospective investigations.

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Abbreviations

ACPAs:

Anti-citrullinated peptide antibodies

AECAs:

Anti-endothelial cell antibodies

AIRDs:

Autoimmune and inflammatory rheumatic diseases

autoAbs:

Autoantibodies

BD:

Behçet’s disease

CCT:

Chaperonin containing t-complex polypeptide 1

E. coli :

Escherichia coli

EGPA:

Eosinophilic granulomatosis with polyangiitis

GCA:

Giant cell arteritis

GPA:

Granulomatosis with polyangiitis

H. pylori :

Helicobacter pylori

Hsp:

Heat shock protein

IL:

Interleukin

JIA:

Juvenile idiopathic arthritis

MPO-ANCA:

Myeloperoxidase-antineutrophil cytoplasmic antibodies

PR3-ANCA:

Peroxidase 3- antineutrophil cytoplasmic antibodies

RA:

Rheumatoid arthritis

SjS:

Sjogren’s syndrome

SLE:

Systemic lupus erythematosus

SpA:

Spondyloarthritis

SSc:

Systemic sclerosis

TA:

Takayasu’s arteritis

TLR:

Toll-like receptor

UCTD:

Undifferentiated connective tissue disease

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Acknowledgements

G.E. is supported by a PhD scholarship funded by the Hellenic State Scholarship Foundation (IKY, Greece).

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Authors and Affiliations

  1. Department of Rheumatology and Clinical Immunology, University General Hospital of Larissa, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece

    Georgios Efthymiou, Lazaros I. Sakkas & Dimitrios P. Bogdanos

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  1. Georgios Efthymiou
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  2. Lazaros I. Sakkas
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  3. Dimitrios P. Bogdanos
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Correspondence to Dimitrios P. Bogdanos .

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Editors and Affiliations

  1. Department of Medicine and Director, Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer Center, University of Toledo, College of Medicine and Life Sciences, Toledo, OH, USA

    Alexzander A. A. Asea

  2. Department of Experimental Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA

    Punit Kaur

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Efthymiou, G., Sakkas, L.I., Bogdanos, D.P. (2019). Anti-human Hsp60 Autoantibodies in Autoimmune and Inflammatory Rheumatic Diseases. In: Asea, A., Kaur, P. (eds) Heat Shock Protein 60 in Human Diseases and Disorders. Heat Shock Proteins, vol 18. Springer, Cham. https://doi.org/10.1007/978-3-030-23154-5_11

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