Skip to main content

Clinical Epidemiology in Rheumatology

  • Chapter
  • First Online:
Absolute Rheumatology Review

Abstract

In this overview, we go over the principal concepts of epidemiology and statistics that are tested regularly in rheumatology board exams. It helps distinguish key type of variables that rheumatologists come across, which are categorical and continuous variables. The chapter also covers measures of central tendency—mean, median, as well as mode. Additionally, it covers distribution of data, which includes standard deviation and interquartile range. Types of study design including case-control, cohort, as well as randomized controlled trials are categorized in detail. Fundamental epidemiological theories including incidence, prevalence, sensitivity, specificity, positive predictive value, negative predictive value, number needed to treat, number needed to harm, and odds ratio are defined, and basic formulas and calculations are described. Furthermore, this chapter describes a few important types of biases that are usually tested on boards. All of these concepts help rheumatologists to read, understand, and apply scientific literature to evidence-based clinical practice.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Reginster JY, et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Lancet. 2001;357(9252):251–6.

    Article  CAS  Google Scholar 

  2. Mayya SS, Monteiro AD, Ganapathy S. Types of biological variables. J Thorac Dis. 2017;9(6):1730–3.

    Article  Google Scholar 

  3. Manikandan S. Measures of dispersion. J Pharmacol Pharmacother. 2011;2(4):315–6.

    Article  CAS  Google Scholar 

  4. Cervera R, et al. Morbidity and mortality in the antiphospholipid syndrome during a 10-year period: a multicentre prospective study of 1000 patients. Ann Rheum Dis. 2015;74(6):1011–8.

    Article  CAS  Google Scholar 

  5. Thiese MS. Observational and interventional study design types; an overview. Biochem Med (Zagreb). 2014;24(2):199–210.

    Article  Google Scholar 

  6. Altman DG, Bland JM. Diagnostic tests. 1: sensitivity and specificity. BMJ. 1994;308(6943):1552.

    Article  CAS  Google Scholar 

  7. Altman DG, Bland JM. Statistics notes: diagnostic tests 2: predictive values. BMJ. 1994;309(6947):102.

    Article  CAS  Google Scholar 

  8. Appel GB, et al. Mycophenolate mofetil versus cyclophosphamide for induction treatment of lupus nephritis. J Am Soc Nephrol. 2009;20(5):1103–12.

    Article  CAS  Google Scholar 

  9. Rothman KJ, Greenland S, Lash TL. Modern epidemiology. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2008.

    Google Scholar 

  10. Cook RJ, Sackett DL. The number needed to treat: a clinically useful measure of treatment effect. BMJ. 1995;310(6977):452.

    Article  CAS  Google Scholar 

  11. Szumilas M. Explaining odds ratios. J Can Acad Child Adolesc Psychiatry. 2010;19(3):227–9.

    Article  Google Scholar 

  12. Jones RB, et al. Mycophenolate mofetil versus cyclophosphamide for remission induction in ANCA-associated vasculitis: a randomised, non-inferiority trial. Ann Rheum Dis. 2019;78(3):399–405.

    Article  CAS  Google Scholar 

  13. Oczkowski SJW. A clinician’s guide to the assessment and interpretation of noninferiority trials for novel therapies. Open Med. 2014;8(2):e67–72.

    PubMed  PubMed Central  Google Scholar 

  14. Vavken P. Rationale for and methods of superiority, noninferiority, or equivalence designs in orthopaedic, controlled trials. Clin Orthop Relat Res. 2011;469(9):2645–53.

    Article  Google Scholar 

  15. Piaggio G, et al. Reporting of noninferiority and equivalence randomized trials: an extension of the CONSORT statement. JAMA. 2006;295(10):1152–60.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Bella Mehta .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Mehta, B. (2020). Clinical Epidemiology in Rheumatology. In: Efthimiou, P. (eds) Absolute Rheumatology Review. Springer, Cham. https://doi.org/10.1007/978-3-030-23022-7_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-23022-7_2

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-23021-0

  • Online ISBN: 978-3-030-23022-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics