Skip to main content

Osteoporosis

  • Chapter
  • First Online:
Absolute Rheumatology Review
  • 1332 Accesses

Abstract

Osteoporosis is the most common metabolic bone disease, and its clinical manifestations result from skeletal fractures. This disease poses a high risk of morbidity and mortality and represents a tremendous economic burden to society. The Dual Energy Absorptiometry Scan (DXA) is the gold standard for diagnosis, and the Fracture Risk Assessment Tool (FRAX) helps in deciding therapeutic interventions in those with osteopenia. The most important management strategy is fracture prevention and treating contributing factors. Both non-pharmacologic and pharmacologic therapies, including patient and provider education, are effective in decreasing the morbidity and mortality of osteoporosis.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. https://www.iofbonehealth.org/facts-and-statistics/calcium-studies-map.

  2. https://www.sheffield.ac.uk/FRAX/.

  3. http://www.twinsuk.ac.uk/wp-content/uploads/2012/03/Zhai.-Osteoporosis.-2008.pdf.

  4. National Osteoporosis Foundation. https://cdn.nof.org/wp-content/uploads/2015/12/Osteoporosis-Fast-Facts.pdf.

  5. Kostenuik PJ. Curr Opin Pharmacol. 2005;5:618–25; Boyle WJ, et al. Nature. 2003;423:337–42; Kostenuik PJ, et al. Curr Pharm Des. 2001;7:613–35.

    Google Scholar 

  6. Feldkamp J, Becker A, Witte OW, Scharff D, Scherbaum WA. Long-term anticonvulsant therapy leads to low bone mineral density–evidence for direct drug effects of phenytoin and carbamazepine on human osteoblast-like cells. Exp Clin Endocrinol Diabetes. 2000;108(1):37–43. https://www.iofbonehealth.org/facts-and-statistics/calcium-studies-map

    Article  Google Scholar 

  7. Albertazzi P, Bottazzi M, Steel SA. Bone mineral density and depot medroxyprogesterone acetate. Contraception. 2006;73(6):577–83. Epub 2006 Apr 27.

    Article  CAS  Google Scholar 

  8. https://www.ncbi.nlm.nih.gov/pubmed/8558225.

  9. https://www.iscd.org/publications/osteoflash/osteoporosis-in-men/.

  10. Journal of Bone and Mineral Research. https://doi.org/10.1002/jbmr.5650040803.

  11. http://www.who.int/chp/topics/Osteoporosis.pdf.

  12. https://www.iscd.org/documents/2014/10/nof-clin-guidelines.pdf/.

  13. Carmel AS, Shieh A, Bang H, Bockman RS. The 25(OH)D level needed to maintain a favorable bisphosphonate response is ≥33 ng/ml. Osteoporos Int. 2012;23(10):2479–87. https://doi.org/10.1007/s00198-011-1868-7. Epub 2012 Jan 12.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Watts NB, Roux C, Modlin JF, Brown JP, Daniels A, Jackson S, Smith S, Zack DJ, Zhou L, Grauer A, Ferrari S. Infections in postmenopausal women with osteoporosis treated with denosumab or placebo: coincidence or causal association? Osteoporos Int. 2012;23(1):327–337. https://doi.org/10.1007/s00198-011-1755-2. Epub 2011 Sep 3.

    Article  Google Scholar 

  15. Andrews EB, Gilsenan AW, Midkiff K, Sherrill B, Wu Y, Mann BH, Masica D. The US postmarketing surveillance study of adult osteosarcoma and teriparatide: study design and findings from the first 7 years. J Bone Miner Res. 2012;27(12):2429–37. https://doi.org/10.1002/jbmr.1768.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. https://www.rheumatology.org/Portals/0/Files/Guideline-for-the-Prevention-and-Treatment-of-GIOP.pdf.

  17. https://www.iofbonehealth.org/facts-statistics#category-19.

  18. http://www.choosingwisely.org/clinician-lists/american-college-rheumatology-routine-repeat-dxa-scans-more-than-once-every-two-years/.

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Aaroop Haridas .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Haridas, A., Berney, S.M. (2020). Osteoporosis. In: Efthimiou, P. (eds) Absolute Rheumatology Review. Springer, Cham. https://doi.org/10.1007/978-3-030-23022-7_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-23022-7_14

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-23021-0

  • Online ISBN: 978-3-030-23022-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics