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Genomic Medicine pp 197–203Cite as

Sinonasal Carcinomas

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Abstract

Sinonasal carcinomas (SNC) comprise a diverse morphologic and genetic spectrum of tumors. NUT carcinoma, SMARCB1-deficient SNC, and sinonasal undifferentiated carcinoma (SNUC) are rare and biologically aggressive, and, although often histologically remarkably similar, these three entities are genetically very distinct. An accurate molecular diagnosis portends a diagnostic value and can identify patients eligible for clinical trials with targeted therapies. Immunohistochemistry (IHC) for NUT and SMARCB1 (INI1) are useful surrogate diagnostic markers in all NUT and SMARCB1-deficient SNC, respectively. IDH2 R172S/T (11C8B1) IHC is a useful adjunct diagnostic marker in at least 70% SNUC.

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Authors and Affiliations

  1. Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Snjezana Dogan

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  1. Snjezana Dogan
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Correspondence to Snjezana Dogan .

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Editors and Affiliations

  1. Dartmouth–Hitchcock Medical Center, Lebanon, NH, USA

    Laura J. Tafe

  2. Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Maria E. Arcila

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Dogan, S. (2020). Sinonasal Carcinomas. In: Tafe, L., Arcila, M. (eds) Genomic Medicine. Springer, Cham. https://doi.org/10.1007/978-3-030-22922-1_13

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  • DOI: https://doi.org/10.1007/978-3-030-22922-1_13

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-22921-4

  • Online ISBN: 978-3-030-22922-1

  • eBook Packages: MedicineMedicine (R0)

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