Skip to main content

The Use of Implantable Cardioverter-Defibrillators in Nonischemic Cardiomyopathy

  • Chapter
  • First Online:
Clinical Controversies in Device Therapy for Cardiac Arrhythmias
  • 248 Accesses

Abstract

In people with cardiac arrest due to ventricular arrhythmia, the application of an electrical shock to the myocardium may terminate the ventricular arrhythmia and resuscitate the patient. In 1985, the approval of the implantable cardioverter-defibrillator made it possible to protect persons at high risk of cardiac arrest. While the first versions of the ICD were bulky and had to be placed in the abdomen with epicardial shock wires placed surgically, improvements in the design has made ICD implantation no more complicated than conventional pacemaker placement. Hence, ICDs today may be implanted in almost any patient and the decision to implant an ICD is based on an assessment of the likelihood of obtaining lifesaving therapy from the device compared to the short- and long-term risks associated with implantation, such as infection and inappropriate shocks.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. The Antiarrhytmics Versus Implantable Defibillators Investigators. A comparison of antiarrhythmic-drug therapy with implantable defibrillators in patients resuscitated from near-fatal ventricular arrhythmias. N Engl J Med. 1997;337:1576–84. https://doi.org/10.1056/NEJM199711273372202.

    Article  Google Scholar 

  2. Connolly SJ, Gent M, Roberts RS, Dorian P, Roy D, Sheldon RS, Mitchell LB, Green MS, Klein GJ, O’Brien B. Canadian Implantable Defibrillator Study (CIDS). Circulation. 2000;101:1297–302. https://doi.org/10.1161/01.CIR.101.11.1297.

    Article  CAS  PubMed  Google Scholar 

  3. Karl-Heinz K, Riccardo C, Jürgen S, Rudolf R. Randomized comparison of antiarrhythmic drug therapy with implantable defibrillators in patients resuscitated from cardiac arrest. Circulation. 2000;102:748–54. https://doi.org/10.1161/01.CIR.102.7.748.

    Article  Google Scholar 

  4. Desai AS, Fang JC, Maisel WH, Baughman KL. Implantable defibrillators for the prevention of mortality in patients with nonischemic cardiomyopathy: a meta-analysis of randomized controlled trials. JAMA. 2004;292:2874–9. https://doi.org/10.1001/jama.292.23.2874.

    Article  CAS  PubMed  Google Scholar 

  5. Connolly SJ, Hallstrom AP, Cappato R, Schron EB, Kuck K-H, Zipes DP, Greene HL, Boczor S, Domanski M, Follmann D, Gent M, Roberts RS. Meta-analysis of the implantable cardioverter defibrillator secondary prevention trials. Eur Heart J. 2000;21:2071–8. https://doi.org/10.1053/euhj.2000.2476.

    Article  CAS  PubMed  Google Scholar 

  6. Bänsch D, Antz M, Boczor S, Volkmer M, Tebbenjohanns J, Seidl K, Block M, Gietzen F, Berger J, Kuck KH. Primary prevention of sudden cardiac death in idiopathic dilated cardiomyopathy: the Cardiomyopathy Trial (CAT). Circulation. 2002;105:1453–8. https://doi.org/10.1161/01.CIR.0000012350.99718.AD.

    Article  PubMed  Google Scholar 

  7. Strickberger SA, Hummel JD, Bartlett TG, Frumin HI, Schuger CD, Beau SL, Bitar C, Morady F, AMIOVIRT Investigators. Amiodarone versus implantable cardioverter-defibrillator:randomized trial in patients with nonischemicdilated cardiomyopathy and asymptomaticnonsustained ventricular tachycardia – AMIOVIRT. J Am Coll Cardiol. 2003;41:1707–12. https://doi.org/10.1016/S0735-1097(03)00297-3.

    Article  PubMed  Google Scholar 

  8. Kadish A, Dyer A, Daubert JP, Quigg R, Estes NAM, Anderson KP, Calkins H, Hoch D, Goldberger J, Shalaby A, Sanders WE, Schaechter A, Levine JH. Prophylactic defibrillator implantation in patients with nonischemic dilated cardiomyopathy. N Engl J Med. 2004;350:2151–8. https://doi.org/10.1056/NEJMoa033088.

    Article  CAS  PubMed  Google Scholar 

  9. Bardy GH, Lee KL, Mark DB, Poole JE, Packer DL, Boineau R, Domanski M, Troutman C, Anderson J, Johnson G, McNulty SE, Clapp-Channing N, Davidson-Ray LD, Fraulo ES, Fishbein DP, Luceri RM, Ip JH. Amiodarone or an implantable cardioverter–defibrillator for congestive heart failure. N Engl J Med. 2005;352:225–37. https://doi.org/10.1056/NEJMoa043399.

    Article  CAS  PubMed  Google Scholar 

  10. Bristow MR, Saxon LA, Boehmer J, Krueger S, Kass DA, De Marco T, Carson P, DiCarlo L, DeMets D, White BG, DeVries DW, Feldman AM. Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure. N Engl J Med. 2004;350:2140–50. https://doi.org/10.1056/NEJMoa032423.

    Article  CAS  PubMed  Google Scholar 

  11. Køber L, Thune JJ, Nielsen JC, Haarbo J, Videbæk L, Korup E, Jensen G, Hildebrandt P, Steffensen FH, Bruun NE, Eiskjær H, Brandes A, Thøgersen AM, Gustafsson F, Egstrup K, Videbæk R, Hassager C, Svendsen JH, Høfsten DE, Torp-Pedersen C, Pehrson S. Defibrillator implantation in patients with nonischemic systolic heart failure. N Engl J Med. 2016;375:1221–30. https://doi.org/10.1056/NEJMoa1608029.

    Article  PubMed  Google Scholar 

  12. Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JGF, Coats AJS, Falk V, González-Juanatey JR, Harjola V-P, Jankowska EA, Jessup M, Linde C, Nihoyannopoulos P, Parissis JT, Pieske B, Riley JP, Rosano GMC, Ruilope LM, Ruschitzka F, Rutten FH, van der Meer P, Filippatos G, McMurray JJV, Aboyans V, Achenbach S, Agewall S, Al-Attar N, Atherton JJ, Bauersachs J, John Camm A, Carerj S, Ceconi C, Coca A, Elliott P, Erol Ç, Ezekowitz J, Fernández-Golfín C, Fitzsimons D, Guazzi M, Guenoun M, Hasenfuss G, Hindricks G, Hoes AW, Iung B, Jaarsma T, Kirchhof P, Knuuti J, Kolh P, Konstantinides S, Lainscak M, Lancellotti P, Lip GYH, Maisano F, Mueller C, Petrie MC, Piepoli MF, Priori SG, Torbicki A, Tsutsui H, van Veldhuisen DJ, Windecker S, Yancy C, Zamorano JL, Zamorano JL, Aboyans V, Achenbach S, Agewall S, Badimon L, Barón-Esquivias G, Baumgartner H, Bax JJ, Bueno H, Carerj S, Dean V, Erol Ç, Fitzsimons D, Gaemperli O, Kirchhof P, Kolh P, Lancellotti P, Lip GYH, Nihoyannopoulos P, Piepoli MF, Ponikowski P, Roffi M, Torbicki A, Vaz Carneiro A, Windecker S, Sisakian HS, Isayev E, Kurlianskaya A, Mullens W, Tokmakova M, Agathangelou P, Melenovsky V, Wiggers H, Hassanein M, Uuetoa T, Lommi J, Kostovska ES, Juillière Y, Aladashvili A, Luchner A, Chrysohoou C, Nyolczas N, Thorgeirsson G, Marc Weinstein J, Di Lenarda A, Aidargaliyeva N, Bajraktari G, Beishenkulov M, Kamzola G, Abdel-Massih T, Celutkiene J, Noppe S, Cassar A, Vataman E, Abir-Khalil S, van Pol P, Mo R, Straburzynska-Migaj E, Fonseca C, Chioncel O, Shlyakhto E, Otasevic P, Goncalvesová E, Lainscak M, Díaz Molina B, Schaufelberger M, Suter T, Yilmaz MB, Voronkov L, Davies C. 2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2016;37:2129–200. https://doi.org/10.1093/eurheartj/ehw128.

    Article  PubMed  Google Scholar 

  13. Al-Khatib SM, Stevenson WG, Ackerman MJ, Bryant WJ, Callans DJ, Curtis AB, Deal BJ, Dickfeld T, Field ME, Fonarow GC, Gillis AM, Granger CB, Hammill SC, Hlatky MA, Joglar JA, Kay GN, Matlock DD, Myerburg RJ, Page RL. 2017 AHA/ACC/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. Heart Rhythm. 2018;15:e190–252. https://doi.org/10.1016/j.hrthm.2017.10.035.

    Article  PubMed  Google Scholar 

  14. Elming MB, Nielsen JC, Haarbo J, Videbæk L, Korup E, Signorovitch J, Olesen LL, Hildebrandt P, Steffensen FH, Bruun NE, Eiskjær H, Brandes A, Thøgersen AM, Gustafsson F, Egstrup K, Videbæk R, Hassager C, Svendsen JH, Høfsten DE, Torp-Pedersen C, Pehrson S, Køber L, Thune JJ. Age and outcomes of primary prevention implantable cardioverter-defibrillators in patients with nonischemic systolic heart failure. Circulation. 2017;136:1772–80. https://doi.org/10.1161/CIRCULATIONAHA.117.028829.

    Article  PubMed  Google Scholar 

  15. Levy WC, Li Y, Reed SD, Zile MR, Shadman R, Dardas T, Whellan DJ, Schulman KA, Ellis SJ, Neilson M, O’Connor CM. Does the implantable cardioverter-defibrillator benefit vary with the estimated proportional risk of sudden death in heart failure patients? JACC Clin Electrophysiol. 2017;3:291–8. https://doi.org/10.1016/j.jacep.2016.09.006.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Barra S, Boveda S, Providência R, Sadoul N, Duehmke R, Reitan C, Borgquist R, Narayanan K, Hidden-Lucet F, Klug D, Defaye P, Gras D, Anselme F, Leclercq C, Hermida J-S, Deharo J-C, Looi K-L, Chow AW, Virdee M, Fynn S, Le Heuzey J-Y, Marijon E, Agarwal S. Adding defibrillation therapy to cardiac resynchronization on the basis of the myocardial substrate. J Am Coll Cardiol. 2017;69:1669–78. https://doi.org/10.1016/j.jacc.2017.01.042.

    Article  PubMed  Google Scholar 

  17. Elming MB, Hammer-Hansen S, Voges I, Nyktari E, Raja AA, Svendsen JH, Pehrson S, Signorovitch J, Køber LV, Prasad SK, Thune JJ. Right ventricular dysfunction and the effect of defibrillator implantation in patients with nonischemic systolic heart failure. Circ Arrhythm Electrophysiol. 2019;12:e007022. https://doi.org/10.1161/CIRCEP.118.007022.

    Article  PubMed  Google Scholar 

  18. Marijon E, Leclercq C, Narayanan K, Boveda S, Klug D, Lacaze-Gadonneix J, Defaye P, Jacob S, Piot O, Deharo J-C, Perier M-C, Mulak G, Hermida J-S, Milliez P, Gras D, Cesari O, Hidden-Lucet F, Anselme F, Chevalier P, Maury P, Sadoul N, Bordachar P, Cazeau S, Chauvin M, Empana J-P, Jouven X, Daubert J-C, Le Heuzey J-Y. Causes-of-death analysis of patients with cardiac resynchronization therapy: an analysis of the CeRtiTuDe cohort study. Eur Heart J. 2015;36:2767–76. https://doi.org/10.1093/eurheartj/ehv455.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jens Jakob Thune .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Thune, J.J., Køber, L. (2019). The Use of Implantable Cardioverter-Defibrillators in Nonischemic Cardiomyopathy. In: Steinberg, J., Epstein, A. (eds) Clinical Controversies in Device Therapy for Cardiac Arrhythmias . Springer, Cham. https://doi.org/10.1007/978-3-030-22882-8_1

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-22882-8_1

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-22881-1

  • Online ISBN: 978-3-030-22882-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics