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Fluorescence Lifetime Imaging Ophthalmoscopy pp 113–116Cite as

FLIO in Mouse Models

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Abstract

FLIO measurement in mouse models has been established in order to investigate effects of specific metabolic, structural, and hereditary conditions on fundus autofluorescence lifetimes. Individual FLIO lifetimes have been defined in pigmented C57BL/6 and non-pigmented albino mice (BALBc). In both mouse models, in contrast to the human retina, fluorescence lifetimes were significantly longer and decreased over time. Additionally, FLIO was performed in a mouse model of spontaneous retinal degeneration and in mouse models of pharmacologically induced retinal degeneration in order to differentiate the contribution of different retinal layers. FLIO measurements in mouse models and in vitro measurements may contribute to a more profound understanding of the origin of fundus fluorophores and their lifetimes, and of (patho)physiological mechanisms in healthy and diseased retinae.

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References

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Author information

Authors and Affiliations

  1. Department of Ophthalmology and Department of Clinical Research, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

    Chantal Dysli, Muriel Dysli & Martin Zinkernagel

Authors
  1. Chantal Dysli
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  2. Muriel Dysli
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  3. Martin Zinkernagel
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Corresponding author

Correspondence to Chantal Dysli .

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Editors and Affiliations

  1. Department of Ophthalmology and Department of Clinical Research, Inselspital Bern University Hospital, University of Bern, Bern, Switzerland

    Martin Zinkernagel

  2. Department of Ophthalmology and Department of Clinical Research, Inselspital Bern University Hospital, University of Bern, Bern, Switzerland

    Chantal Dysli

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Dysli, C., Dysli, M., Zinkernagel, M. (2019). FLIO in Mouse Models. In: Zinkernagel, M., Dysli, C. (eds) Fluorescence Lifetime Imaging Ophthalmoscopy. Springer, Cham. https://doi.org/10.1007/978-3-030-22878-1_18

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  • DOI: https://doi.org/10.1007/978-3-030-22878-1_18

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-22877-4

  • Online ISBN: 978-3-030-22878-1

  • eBook Packages: MedicineMedicine (R0)

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