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Age-Related Macular Degeneration

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Fluorescence Lifetime Imaging Ophthalmoscopy

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Abstract

Age-related macular degeneration (AMD) is a disorder of the central retina with increasing prevalence in the elderly population leading to severe vision loss over time. Different stages of AMD include early, intermediate and late AMD, latter summarizing exudative and non-exudative/atrophic forms of AMD. Different studies investigated FLIO in the respective stages of disease. In early AMD, a ring shaped prolongation of FLIO lifetimes can be seen. Drusenoid deposits may feature characteristic FLIO distribution depending on the configuration and location of the retinal deposits. In late AMD with geographic atrophy, generally prolonged FLIO lifetimes are measured, however, macular pigment in remaining photoreceptor segments within the central macula may lead to increased contribution of short lifetimes.

FLIO features characteristic lifetime patterns in AMD and may be used for diagnostic purposes for early retinal changes, and for monitoring of disease progression.

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Authors and Affiliations

  1. Department of Ophthalmology and Department of Clinical Research, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

    Chantal Dysli

  2. Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, UT, USA

    Lydia Sauer

Authors
  1. Chantal Dysli
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  2. Lydia Sauer
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Correspondence to Chantal Dysli .

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Editors and Affiliations

  1. Department of Ophthalmology and Department of Clinical Research, Inselspital Bern University Hospital, University of Bern, Bern, Switzerland

    Martin Zinkernagel

  2. Department of Ophthalmology and Department of Clinical Research, Inselspital Bern University Hospital, University of Bern, Bern, Switzerland

    Chantal Dysli

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Dysli, C., Sauer, L. (2019). Age-Related Macular Degeneration. In: Zinkernagel, M., Dysli, C. (eds) Fluorescence Lifetime Imaging Ophthalmoscopy. Springer, Cham. https://doi.org/10.1007/978-3-030-22878-1_10

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  • DOI: https://doi.org/10.1007/978-3-030-22878-1_10

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-22877-4

  • Online ISBN: 978-3-030-22878-1

  • eBook Packages: MedicineMedicine (R0)

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