Abstract
Patients sometimes say they have “low metabolism,” which prevents them from losing weight. While there is substantial variability, metabolic rate is generally directly related to total body and lean mass. Ultimately, the difficulty in losing weight relates to greater energy intake than energy expenditure. While genetics and secondary causes of obesity are important, monogenic and secondary causes of obesity are rare. A thorough history and physical exam can help guide any necessary workup of weight gain due to medications or various endocrine disorders. To achieve weight loss, a patient must create a calorie deficit through dietary modification (i.e., calorie restriction), physical activity, or a combination of the two. Although patients often under-report their calorie intake, comprehensive lifestyle interventions can provide effective education and lead to significant weight loss. This chapter discusses new concepts in eating patterns such as intermittent fasting and time restricted feeding which are being studied in the context of weight loss. FDA-approved anti-obesity medications can also be excellent adjuncts to behavioral modification. Patient education and engagement are key to establishing a good provider-patient relationship and shared decision-making can provide patients who have weight struggles with the empowerment to successfully lose weight.
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References
Gonzalez-Muniesa P, et al. Obesity. Nat Rev Dis Primers. 2017;3:17034.
Levin BE. Developmental gene x environment interactions affecting systems regulating energy homeostasis and obesity. Front Neuroendocrinol. 2010;31(3):270–83.
Jensen MD, et al. 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society. J Am Coll Cardiol. 2014;63(25 Pt B):2985–3023.
Tsai AG, Wadden TA. In the clinic: obesity. Ann Intern Med. 2013;159(5):ITC3–1-ITC3-15; quiz ITC3-16.
Steele CB, et al. Vital signs: trends in incidence of cancers associated with overweight and obesity - United States, 2005-2014. MMWR Morb Mortal Wkly Rep. 2017;66(39):1052–8.
Ravussin E, et al. Twenty-four-hour energy expenditure and resting metabolic rate in obese, moderately obese, and control subjects. Am J Clin Nutr. 1982;35(3):566–73.
Ravussin E, et al. Reduced rate of energy expenditure as a risk factor for body-weight gain. N Engl J Med. 1988;318(8):467–72.
Skov AR, et al. Normal levels of energy expenditure in patients with reported “low metabolism”. Clin Physiol. 1997;17(3):279–85.
Carneiro IP, et al. Is obesity associated with altered energy expenditure. Adv Nutr. 2016;7(3):476–87.
Westerterp KR. Impacts of vigorous and non-vigorous activity on daily energy expenditure. Proc Nutr Soc. 2003;62(3):645–50.
de Jonge L, Bray GA. The thermic effect of food and obesity: a critical review. Obes Res. 1997;5(6):622–31.
Nielsen S, et al. Body composition and resting energy expenditure in humans: role of fat, fat-free mass, and extracellular fluid. Int J Obes Relat Metab Disord. 2000;24(9):1153–7.
Rankinen T, et al. The human obesity gene map: the 2005 update. Obesity (Silver Spring). 2006;14(4):529–644.
Melmed S, et al. Williams textbook of endocrinology. Philadelphia: Elsevier; 2016. p. xviii, 1916 pages
Barnes RD, Ivezaj V. A systematic review of motivational interviewing for weight loss among adults in primary care. Obes Rev. 2015;16(4):304–18.
Kahan S, Wilson DK, Sweeney AM. The role of behavioral medicine in the treatment of obesity in primary care. Med Clin North Am. 2018;102(1):125–33.
Kahan S., Manson JE. Obesity treatment, beyond the guidelines: practical suggestions for clinical practice. JAMA. 2019;321(14):1349–50.
Mechanick JI, et al. Clinical practice guidelines for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient--2013 update: cosponsored by American Association of Clinical Endocrinologists, the Obesity Society, and American Society for Metabolic & Bariatric Surgery. Obesity (Silver Spring). 2013;21(Suppl 1):S1–27.
Force ABET, et al. ASGE position statement on endoscopic bariatric therapies in clinical practice. Gastrointest Endosc. 2015;82(5):767–72.
Lichtman SW, et al. Discrepancy between self-reported and actual caloric intake and exercise in obese subjects. N Engl J Med. 1992;327(27):1893–8.
Catenacci VA, et al. A randomized pilot study comparing zero-calorie alternate-day fasting to daily caloric restriction in adults with obesity. Obesity (Silver Spring). 2016;24(9):1874–83.
Gabel K, et al. Effects of 8-hour time-restricted feeding on body weight and metabolic disease risk factors in obese adults: a pilot study. Nutr Healthy Aging. 2018;4(4):345–53.
Kaptein EM, Beale E, Chan LS. Thyroid hormone therapy for obesity and nonthyroidal illnesses: a systematic review. J Clin Endocrinol Metab. 2009;94(10):3663–75.
Pearce EN. Thyroid hormone and obesity. Curr Opin Endocrinol Diabetes Obes. 2012;19(5):408–13.
Lorello C, Goldfield GS, Doucet E. Methylphenidate hydrochloride increases energy expenditure in healthy adults. Obesity (Silver Spring). 2008;16(2):470–2.
Bessesen DH, Van Gaal LF. Progress and challenges in anti-obesity pharmacotherapy. Lancet Diabetes Endocrinol. 2018;6(3):237–48.
Harpaz E, et al. The effect of caffeine on energy balance. J Basic Clin Physiol Pharmacol. 2017;28(1):1–10.
Whiting S, Derbyshire EJ, Tiwari B. Could capsaicinoids help to support weight management? A systematic review and meta-analysis of energy intake data. Appetite. 2014;73:183–8.
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Iwamoto, S.J., Cornier, MA. (2019). Help, My Metabolism Is Low!. In: McDermott, M. (eds) Management of Patients with Pseudo-Endocrine Disorders. Springer, Cham. https://doi.org/10.1007/978-3-030-22720-3_7
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DOI: https://doi.org/10.1007/978-3-030-22720-3_7
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