Abstract
Large cell neuroendocrine carcinoma (LCNEC) was originally separated from atypical carcinoids based on a worse prognosis. It is characterized by neuroendocrine morphology and expression of neuroendocrine markers. The cells are larger compared to SCLC and possess enlarged nucleoli and a coarse chromatin. Together with SCLC it forms the complex of high-grade neuroendocrine carcinomas of the lung. As SCLC LCNEC can occur in other organs, but is much more common in the lung.
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Popper, H., Murer, B. (2020). Large Cell Neuroendocrine Carcinoma. In: Pulmonary Pathology. Essentials of Diagnostic Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-22664-0_5
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DOI: https://doi.org/10.1007/978-3-030-22664-0_5
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