The Human Genome Project Era
This chapter describes the history of modern-day psychiatric genetics, beginning with the linkage studies of the late 1980s, the candidate-gene studies of the 1990s, and the genome-wide association studies that continue to the present day. Despite all the media hype, scientists have not found one gene for mental illness, because no such gene exists. The meaning of the phrase “a gene for” mental illness or any other trait is discussed. This chapter features my visit to the laboratory of Richard Huganir, Director of both the Department of Neuroscience and the Kavli Neuroscience Discovery Institute at the Johns Hopkins Medical Institutions.