Skip to main content
SpringerLink
Log in

Pancreas Tumors Laser Ablation

  • Chapter
  • First Online:
Image-guided Laser Ablation

Abstract

Most patients with pancreatic cancer (PC) suffer from an unresectable tumor at the time of diagnosis with limited treatment effectiveness. Laser ablation (LA) is a new tool to fight PC and liver and thyroid tumors. The use of bare-tip thin fibers enables PC treatment in difficult and at-risk locations. Initial studies of case reports investigating the feasibility and safety of locally advanced and metastatic LA for PC have shown that this minimally invasive technique is useful and safe in patients with unresectable PC. It could be a promising alternative to surgery in selected cases in the future, gaining more experience.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 49.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 64.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 89.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Vincent A, Herman J, Schulick R, Hruban RH, Goggins M. Pancreatic cancer. Lancet. 2011;378(9791):607–20.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Tempero MA, Arnoletti JP, Behrman SW, Ben-Josef E, Benson AB 3rd, Casper ES, et al. Pancreatic adenocarcinoma, version 2.2012: featured updates to the NCCN guidelines. J Natl Compr Cancer Netw. 2012;10(6):703–13.

    Article  CAS  Google Scholar 

  3. Gillams A, Goldberg N, Ahmed M, Bale R, Breen D, Callstrom M, et al. Thermal ablation of colorectal liver metastases: a position paper by an international panel of ablation experts, the interventional oncology sans Frontieres meeting 2013. Eur Radiol. 2015;25(12):3438–54.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Ahmed M, Brace CL, Lee FT Jr, Goldberg SN. Principles of and advances in percutaneous ablation. Radiology. 2011;258(2):351–69.

    Article  PubMed  Google Scholar 

  5. Di Matteo F, Martino M, Rea R, Pandolfi M, Panzera F, Stigliano E, et al. US-guided application of Nd:YAG laser in porcine pancreatic tissue: an ex vivo study and numerical simulation. Gastrointest Endosc. 2013;78(5):750–5.

    Article  PubMed  Google Scholar 

  6. Schena E, Majocchi L. Assessment of temperature measurement error and its correction during Nd:YAG laser ablation in porcine pancreas. Int J Hyperth. 2014;30(5):328–34.

    Article  Google Scholar 

  7. Ungureanu B, Pirici D, Mărgăritescu C, S L, Pătraşcu S, Şurlin V, et al. Endoscopic ultrasound-guided radiofrequency ablation of the pancreas: an experimental study with pathological correlation. Endoscopic Ultrasound. 2016;4:330–5.

    Google Scholar 

  8. Luo XM, Niu LZ, Chen JB, Xu KC. Advances in cryoablation for pancreatic cancer. World J Gastroenterol. 2016;22(2):790–800.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Linecker M, Pfammatter T, Kambakamba P, DeOliveira ML. Ablation strategies for locally advanced pancreatic cancer. Dig Surg. 2016;33(4):351–9.

    Article  PubMed  Google Scholar 

  10. Duprè A, Melodelima D, Pflieger H, Chen Y, Vincenot J, Kocot A, et al. Thermal ablation of the pancreas with intraoperative high-intensity focused ultrasound: safety and efficacy in a porcine model. Pancreas. 2017;46(2):219–24.

    Article  PubMed  Google Scholar 

  11. Pacella CM, Francica G, Di Lascio FM, Arienti V, Antico E, Caspani B, et al. Long-term outcome of cirrhotic patients with early hepatocellular carcinoma treated with ultrasound-guided percutaneous laser ablation: a retrospective analysis. J Clin Oncol. 2009;27(16):2615–21.

    Article  PubMed  Google Scholar 

  12. Oto A, Sethi I, Karczmar G, McNichols R, Ivancevic MK, Stadler WM, et al. MR imaging-guided focal laser ablation for prostate cancer: phase I trial. Radiology. 2013;267(3):932–40.

    Article  PubMed  Google Scholar 

  13. Mou Y, Zhao Q, Zhong L, Chen F, Jiang T. Preliminary results of ultrasound-guided laser ablation for unresectable metastases to retroperitoneal and hepatic portal lymph nodes. World J Surg Oncol. 2016;14(1):165.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Sartori S, Mauri G, Tombesi P, Di Vece F, Bianchi L, Pacella CM. Ultrasound-guided percutaneous laser ablation is safe and effective in the treatment of small renal tumors in patients at increased bleeding risk. Int J Hyperth. 2018;35(1):19–25.

    Article  Google Scholar 

  15. Zhou W, Jiang S, Zhan W, Zhou J, Xu S, Zhang L. Ultrasound-guided percutaneous laser ablation of unifocal T1N0M0 papillary thyroid microcarcinoma: preliminary results. Eur Radiol. 2017;27(7):2934–40.

    Article  PubMed  Google Scholar 

  16. Francica G, Petrolati A, Di Stasio E, Pacella S, Stasi R, Pacella CM. Effectiveness, safety, and local progression after percutaneous laser ablation for hepatocellular carcinoma nodules up to 4 cm are not affected by tumor location. AJR Am J Roentgenol. 2012;199(6):1393–401.

    Article  PubMed  Google Scholar 

  17. Pacella CM, Bizzarri G, Francica G, Bianchini A, De Nuntis S, Pacella S, et al. Percutaneous laser ablation in the treatment of hepatocellular carcinoma with small tumors: analysis of factors affecting the achievement of tumor necrosis. J Vasc Interv Radiol. 2005;16(11):1447–57.

    Article  PubMed  Google Scholar 

  18. Di Matteo F, Martino M, Rea R, Pandolfi M, Rabitti C, Masselli GM, et al. EUS-guided Nd:YAG laser ablation of normal pancreatic tissue: a pilot study in a pig model. Gastrointest Endosc. 2010;72(2):358–63.

    Article  PubMed  Google Scholar 

  19. Di Matteo F, Picconi F, Martino M, Pandolfi M, Pacella CM, Schena E, et al. Endoscopic ultrasound-guided Nd:YAG laser ablation of recurrent pancreatic neuroendocrine tumor: a promising revolution? Endoscopy. 2014;46(Suppl 1 UCTN):E380–1.

    PubMed  Google Scholar 

  20. Jiang T, Deng Z, Li J, Tian G. Pancreatic cancer: does it work if EUS and laser ablation get married? Endosc Ultrasound. 2018;7(3):207–9.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Di Matteo FM, Saccomandi P, Martino M, Pandolfi M, Pizzicannella M, Balassone V, et al. Feasibility of EUS-guided Nd:YAG laser ablation of unresectable pancreatic adenocarcinoma. Gastrointest Endosc. 2018;88(1):168–74 e1.

    Article  PubMed  Google Scholar 

  22. Jiang T, Deng Z, Tian G, Chen F, Bao H, Li J, et al. Percutaneous laser ablation: a new contribution to unresectable high-risk metastatic retroperitoneal lesions? Oncotarget. 2017;8(2):2413–22.

    PubMed  Google Scholar 

  23. Di Matteo F, Grasso R, Pacella CM, Martino M, Pandolfi M, Rea R, et al. EUS-guided Nd:YAG laser ablation of a hepatocellular carcinoma in the caudate lobe. Gastrointest Endosc. 2011;73(3):632–6.

    Article  PubMed  Google Scholar 

  24. Camellini L, Carlinfante G, Azzolini F, Iori V, Cavina M, Sereni G, et al. A randomized clinical trial comparing 22G and 25G needles in endoscopic ultrasound-guided fine-needle aspiration of solid lesions. Endoscopy. 2011;43(8):709–15.

    Article  CAS  PubMed  Google Scholar 

  25. Tian G, Bao H, Li J, Jiang T. Systematic review and meta-analysis of diagnostic accuracy of endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) using 22-gauge and 25-gauge needles for pancreatic masses. Med Sci Monit. 2018;24:8333–41.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Sreenarasimhaiah J. Interventional endoscopic ultrasound: the next frontier in gastrointestinal endoscopy. Am J Med Sci. 2009;338(4):319–24.

    Article  PubMed  Google Scholar 

  27. Chan HH, Nishioka NS, Mino M, Lauwers GY, Puricelli WP, Collier KN, et al. EUS-guided photodynamic therapy of the pancreas: a pilot study. Gastrointest Endosc. 2004;59(1):95–9.

    Article  PubMed  Google Scholar 

  28. Yusuf TE, Matthes K, Brugge WR. EUS-guided photodynamic therapy with verteporfin for ablation of normal pancreatic tissue: a pilot study in a porcine model (with video). Gastrointest Endosc. 2008;67(6):957–61.

    Article  PubMed  Google Scholar 

  29. Irisawa A, Takagi T, Kanazawa M, Ogata T, Sato Y, Takenoshita S, et al. Endoscopic ultrasound-guided fine-needle injection of immature dendritic cells into advanced pancreatic cancer refractory to gemcitabine: a pilot study. Pancreas. 2007;35(2):189–90.

    Article  PubMed  Google Scholar 

  30. Carrara S, Arcidiacono PG, Albarello L, Addis A, Enderle MD, Boemo C, et al. Endoscopic ultrasound-guided application of a new hybrid cryotherm probe in porcine pancreas: a preliminary study. Endoscopy. 2008;40(4):321–6.

    Article  CAS  PubMed  Google Scholar 

  31. Wolfgang CL, Herman JM, Laheru DA, Klein AP, Erdek MA, Fishman EK, et al. Recent progress in pancreatic cancer. CA Cancer J Clin. 2013;63(5):318–48.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Oken MM, Creech RH, Tormey DC, Horton J, Davis TE, McFadden ET, et al. Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol. 1982;5(6):649–55.

    Article  CAS  PubMed  Google Scholar 

  33. Rustagi T, Chhoda A. Endoscopic radiofrequency ablation of the pancreas. Dig Dis Sci. 2017;62(4):843–50.

    Article  PubMed  Google Scholar 

  34. Schena E, Saccomandi P, Giurazza F, Caponero MA, Mortato L, Di Matteo FM, et al. Experimental assessment of CT-based thermometry during laser ablation of porcine pancreas. Phys Med Biol. 2013;58(16):5705–16.

    Article  CAS  PubMed  Google Scholar 

  35. Pacella CM, Rossi Z, Bizzarri G, Papiini E, Marinozzi V, Paliotta D, et al. Ultrasound-guided percutaneous laser ablation of liver tissue in a rabbit model. Eur Radiol. 1993;3:26–32.

    Article  Google Scholar 

  36. Cotton PB, Eisen GM, Aabakken L, Baron TH, Hutter MM, Jacobson BC, et al. A lexicon for endoscopic adverse events: report of an ASGE workshop. Gastrointest Endosc. 2010;71(3):446–54.

    Article  PubMed  Google Scholar 

  37. von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP, et al. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet. 2007;370(9596):1453–7.

    Article  Google Scholar 

  38. Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 1993;85(5):365–76.

    Article  CAS  PubMed  Google Scholar 

  39. Sacks D, McClenny TE, Cardella JF, Lewis CA. Society of Interventional Radiology clinical practice guidelines. J Vasc Interv Radiol. 2003;14(9Pt 2):S199–202.

    Article  PubMed  Google Scholar 

  40. Ahmed M, Solbiati L, Brace CL, Breen DJ, Callstrom MR, Charboneau JW, et al. Image-guided tumor ablation: standardization of terminology and reporting criteria—a 10-year update. Radiology. 2014;273(1):241–60.

    Article  PubMed  Google Scholar 

  41. Ofosu A, Ramai D, Adler DG. Endoscopic ultrasound-guided ablation of pancreatic cystic neoplasms: ready for prime time? Ann Gastroenterol. 2019;32(1):39–45.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Ultrasound, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China

    Tian’an Jiang

  2. Department of Interventional Ultrasound, Chinese PLA General Hospital, Beijing, China

    Ping Liang & Jie Yu

Authors
  1. Tian’an Jiang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ping Liang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jie Yu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Tian’an Jiang .

Editor information

Editors and Affiliations

  1. Department of Interventional Radiology, Ospedale Regina Apostolorum, Albano Laziale, Rome, Italy

    Claudio Maurizio Pacella

  2. Department of Ultrasound, Zhejiang University, Hangzhou, China

    Tian'an Jiang

  3. Division of Interventional Radiology, European Institute of Oncology, IRCCS, Milan, Italy

    Giovanni Mauri

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Jiang, T., Liang, P., Yu, J. (2020). Pancreas Tumors Laser Ablation. In: Pacella, C., Jiang, T., Mauri, G. (eds) Image-guided Laser Ablation. Springer, Cham. https://doi.org/10.1007/978-3-030-21748-8_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-21748-8_11

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-21747-1

  • Online ISBN: 978-3-030-21748-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation