Endocannabinoid System Components: Overview and Tissue Distribution

  • Neal Joshi
  • Emmanuel S. OnaiviEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1162)


Marijuana/cannabinoid research has been transformed into mainstream science during the last half-century. Evidence based research and remarkable biotechnological advances demonstrate that phytocannabinoids and endocannabinoid (eCBs) acting on cannabinoid receptors (CBRs) regulate various aspects of human physiological, behavioral, immunological and metabolic functions. The distribution and function of the components of the endocannabinoid system (ECS) in the central nervous system (CNS) and immune processes have garnished significant research focus with major milestones. With these advances in biotechnology, rapid extension of the ECS research in the periphery has gained momentum. In this chapter, we review the components and tissue distribution of this previously unknown but ubiquitous and complex ECS that is involved in almost all aspects of mammalian physiology and pathology.


Cannabis Cannabinoids Endocannabinoids Cannabinoid receptors 



2-arachidonyl glycerol


cannabinoid receptors


central nervous system




endocannabinoid system


enteric nervous system


endoplasmic reticulum


gamma-aminobutyric acid




mitochondrial cannabinoid receptor


nucleus accumbens


phosphor-cAMP response element-binding protein


peroxisome proliferator-activated receptors




transient receptor potential vanilloid type 1


cannabinoid receptor gene


G-protein coupled receptor


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Rowan University School of Osteopathic MedicineStratfordUSA
  2. 2.Department of BiologyWilliam Paterson UniversityWayneUSA

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