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Italian Workshop on Artificial Life and Evolutionary Computation

WIVACE 2018: Artificial Life and Evolutionary Computation pp 115–126Cite as

Synchronization Effects in a Metabolism-Driven Model of Multi-cellular System

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Part of the book series: Communications in Computer and Information Science ((CCIS,volume 900))

Abstract

Understanding the synchronization, either induced or spontaneous, of cell growth, division and proliferation in a cell culture is an important topic in molecular biology and biotechnology. Metabolic processes related to the synthesis of all the molecules needed for a new round of cell division are the basic underlying phenomena responsible for the behaviour of the population. Complex dynamics, such as population oscillations, arise when the individual members of a population divide in unison. To investigate the conditions that can determine oscillatory behaviors, we here use a multi-scale model that couples the simulation of metabolic growth, via metabolic network modelling and Flux Balance Analysis, with the simulation of population and spatial dynamics, via Cellular Potts Models. We here show that repeated oscillations in the overall number of cells spontaneously emerge, due to the synchronization of duplication events, unless cell density-dependent controls on growth are introduced.

D. Maspero, A. Graudenzi and D. Chiara—Equal contributors.

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Author information

Authors and Affiliations

  1. Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy

    Davide Maspero

  2. Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

    Davide Maspero

  3. Department of Informatics, Systems and Communication, University of Milan-Bicocca, Milan, Italy

    Alex Graudenzi, Satwinder Singh, Giancarlo Mauri, Marco Antoniotti & Chiara Damiani

  4. Department of Statistics and Quantitative Methods, University of Milan-Bicocca, Milan, Italy

    Dario Pescini

  5. SYSBIO Centre of Systems Biology, University of Milano-Bicocca, Milan, Italy

    Chiara Damiani

  6. NeuroMI Milan Center for Neuroscience, University of Milano-Bicocca, Milan, Italy

    Marco Antoniotti

Authors
  1. Davide Maspero
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  2. Alex Graudenzi
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  3. Satwinder Singh
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  4. Dario Pescini
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  5. Giancarlo Mauri
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  6. Marco Antoniotti
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  7. Chiara Damiani
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Corresponding authors

Correspondence to Alex Graudenzi or Chiara Damiani .

Editor information

Editors and Affiliations

  1. University of Parma, Parma, Italy

    Stefano Cagnoni

  2. University of Parma, Parma, Italy

    Monica Mordonini

  3. Università degli Studi eCampus, Novedrate, Italy

    Riccardo Pecori

  4. University of Bologna, Cesena, Italy

    Andrea Roli

  5. University of Modena and Reggio Emilia, Modena, Italy

    Marco Villani

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Maspero, D. et al. (2019). Synchronization Effects in a Metabolism-Driven Model of Multi-cellular System. In: Cagnoni, S., Mordonini, M., Pecori, R., Roli, A., Villani, M. (eds) Artificial Life and Evolutionary Computation. WIVACE 2018. Communications in Computer and Information Science, vol 900. Springer, Cham. https://doi.org/10.1007/978-3-030-21733-4_9

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  • DOI: https://doi.org/10.1007/978-3-030-21733-4_9

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-21732-7

  • Online ISBN: 978-3-030-21733-4

  • eBook Packages: Computer ScienceComputer Science (R0)

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