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Super-Resolution Imaging Based on Nonlinear Plasmonic Scattering

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Label-Free Super-Resolution Microscopy

Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

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Abstract

During the last two decades, the resolution limit was well overcome by manipulating nonlinearity of fluorescence emission, including on/off switching and saturation, enabling resolution below 100 nm. However, fluorescence suffers from intrinsic photo-bleaching, which aggravates with repeated excitation for on/off switching or strong incident power for achieving saturation. Therefore, it is more than desirable to develop super-resolution imaging modality based on an alternative contrast agent without bleaching, such as scattering. An attractive candidate is scattering from surface plasmon resonance (SPR) nanostructures, whose scattering intensity is particularly strong, and can be spectrally tuned by structure. In this chapter, we review recent finding of nonlinear scattering , including saturation , reverse saturation , and all-optical switching, in an isolated plasmonic nanostructure. These nonlinear behaviours have been successfully applied to imaging, bringing spatial resolution down to nearly λ/10, which is enough to resolve surface plasmon polariton in nanoscale optoelectronic devices without labelling. Potential applications range from bio-medical imaging and functional plasmonic nanostructures. Our results are expected to be a stimulating example in finding more exotic contrast agency for improving optical resolution.

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Authors and Affiliations

  1. Department of Physics, National Taiwan University, No.1, Sec. 4, Roosevelt Rd., Taipei, 10617, Taiwan (R.O.C.)

    Tushar C. Jagadale & Shi-Wei Chu

  2. Technical Physics Division, Bhabha Atomic Research Centre, Mumbai, 400085, India

    Tushar C. Jagadale

  3. Molecular Imaging Centre, National Taiwan University, No.1, Sec. 4, Roosevelt Rd., Taipei, 10617, Taiwan (R.O.C.)

    Shi-Wei Chu

Authors
  1. Tushar C. Jagadale
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  2. Shi-Wei Chu
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Correspondence to Shi-Wei Chu .

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Editors and Affiliations

  1. University of North Carolina at Charlotte, Charlotte, NC, USA

    Vasily Astratov

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Jagadale, T.C., Chu, SW. (2019). Super-Resolution Imaging Based on Nonlinear Plasmonic Scattering. In: Astratov, V. (eds) Label-Free Super-Resolution Microscopy. Biological and Medical Physics, Biomedical Engineering. Springer, Cham. https://doi.org/10.1007/978-3-030-21722-8_10

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