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Genomics of Visceral Pain

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Genomics of Pain and Co-Morbid Symptoms

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Abstract

Visceral pain is one of the most common pain conditions and among the top causes of disability worldwide. Visceral pain may be associated with a specific pathology such as gastroenteritis, inflammatory conditions; however, most chronic visceral pain does not have an identifiable pathophysiological origin that is known. The characterization of visceral pain in terms of location, intensity, and severity of symptoms for phenotyping and investigation of underlying mechanisms is of upmost important to better understand not only the underlying mechanisms but ultimately the treatment for this chronic debilitating painful symptom. The following chapter will review the state-of-the-science on the genomics of visceral pain and comorbid symptoms (stress and sleep disturbance) and review methods of phenotyping visceral pain and the multi-omic methods for measurement. Additional focus will include current challenges and areas of future discovery.

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Acknowledgements

Alan Hoofring, National Institutes of Health, Medical Arts for illustrations. Conceptual contributions from prior Henderson Lab members: Tara J.Taylor, Nicolaas H. Fourie, LeeAnne B. Sherwin, Kristen R. Weaver, Arsemia Del Valle Pinero. Acknowledgments and mentoring support from Margaret M. Heitkemper and John W. Wiley.

The authors acknowledge funding from the United States Department of Health and Human Services, National Institutes of Health, National Institute of Nursing Research, Division of Intramural Research to Wendy A. Henderson, 1ZIANR000018; National Institute on Minority Health & Health Disparities, NIH fellowship DREAM award to Bridgett Rahim-Williams, 1K22MD006143; Bethesda, Maryland, USA.

The opinions expressed herein and the interpretation and reporting of these data are the responsibility of the author(s) and should not be seen as an official recommendation, interpretation, or policy of the National Institutes of Health or the United States Government.

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Authors and Affiliations

  1. University of Connecticut School of Nursing, Storrs, CT, USA

    Wendy A. Henderson

  2. University of North Florida, Jacksonville, FL, USA

    Bridgett Rahim-Williams

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  1. Wendy A. Henderson
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  2. Bridgett Rahim-Williams
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Correspondence to Wendy A. Henderson .

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Editors and Affiliations

  1. Department of Pain and Translational Symptom Science, University of Maryland School of Nursing, Baltimore, MD, USA

    Susan G. Dorsey

  2. University of Connecticut School of Nursing, Storrs, CT, USA

    Angela R. Starkweather

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Henderson, W.A., Rahim-Williams, B. (2020). Genomics of Visceral Pain. In: Dorsey, S., Starkweather, A. (eds) Genomics of Pain and Co-Morbid Symptoms. Springer, Cham. https://doi.org/10.1007/978-3-030-21657-3_9

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  • DOI: https://doi.org/10.1007/978-3-030-21657-3_9

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