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Placebo Hypoalgesic Effects and Genomics

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Genomics of Pain and Co-Morbid Symptoms

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Abstract

Genomic studies on the placebo hypoalgesic effects highlight a promising link between single nucleotide polymorphisms (SNPs) in the dopamine, opioid, and endocannabinoid genes and placebo hypoalgesia. Yet, epistasis, replication, GWAS, and omics studies are missing. In this chapter, we elaborate upon the state-of-the-science of the genomics of the placebo and nocebo effect across pain conditions and populations with a focus on current challenges and areas of future discovery. We indicate directions for future research that will help fully understand the complexity of placebo effects and molecular mechanisms that predict individuals who may display a placebo effect.

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Acknowledgments

This research is supported by NIDCR (R01 DE025946).

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None.

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Authors and Affiliations

  1. Department of Pain and Translational Symptom Science, School of Nursing, University of Maryland, Baltimore, MD, USA

    Luana Colloca & Nandini Raghuraman

  2. Departments of Anesthesiology and Psychiatry, School of Medicine, University of Maryland, Baltimore, MD, USA

    Luana Colloca

  3. Center to Advance Chronic Pain Research, University of Maryland, Baltimore, MD, USA

    Luana Colloca

  4. Program in Epidemiology and Human Genetics, University of Maryland School of Medicine, Baltimore, MD, USA

    Nandini Raghuraman

Authors
  1. Luana Colloca
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  2. Nandini Raghuraman
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Correspondence to Luana Colloca .

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Editors and Affiliations

  1. Department of Pain and Translational Symptom Science, University of Maryland School of Nursing, Baltimore, MD, USA

    Susan G. Dorsey

  2. University of Connecticut School of Nursing, Storrs, CT, USA

    Angela R. Starkweather

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Colloca, L., Raghuraman, N. (2020). Placebo Hypoalgesic Effects and Genomics. In: Dorsey, S., Starkweather, A. (eds) Genomics of Pain and Co-Morbid Symptoms. Springer, Cham. https://doi.org/10.1007/978-3-030-21657-3_15

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  • DOI: https://doi.org/10.1007/978-3-030-21657-3_15

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