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Spinal Cord Injury-Related Pain and Genomics

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Genomics of Pain and Co-Morbid Symptoms

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Abstract

Spinal cord injury is a heterogenous condition characterized by destruction of cells and tissues of the central nervous system and there is a high propensity for the injury to result in chronic pain. Prior research on the mechanisms of pain following spinal cord injury has been difficult to replicate due to differences in the categorization of pain type(s) and inconsistent use of measures to phenotype pain across studies. Plausible mechanisms underlying the development and maintenance of spinal cord injury-related pain overlap with the pathophysiology of secondary injury as well as other chronic pain conditions. Current research in the field to identify biological markers, including genomics, is discussed with implications for future research in humans.

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Author information

Authors and Affiliations

  1. University of Connecticut School of Nursing, Storrs, CT, USA

    Angela R. Starkweather

  2. Department of Pain and Translational Symptom Science, University of Maryland School of Nursing, Baltimore, MD, USA

    Susan G. Dorsey

Authors
  1. Angela R. Starkweather
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  2. Susan G. Dorsey
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Correspondence to Angela R. Starkweather .

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Editors and Affiliations

  1. Department of Pain and Translational Symptom Science, University of Maryland School of Nursing, Baltimore, MD, USA

    Susan G. Dorsey

  2. University of Connecticut School of Nursing, Storrs, CT, USA

    Angela R. Starkweather

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Starkweather, A.R., Dorsey, S.G. (2020). Spinal Cord Injury-Related Pain and Genomics. In: Dorsey, S., Starkweather, A. (eds) Genomics of Pain and Co-Morbid Symptoms. Springer, Cham. https://doi.org/10.1007/978-3-030-21657-3_13

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  • DOI: https://doi.org/10.1007/978-3-030-21657-3_13

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-21656-6

  • Online ISBN: 978-3-030-21657-3

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