Abstract
Vascular calcification is the process of calcium salt precipitation in vessel walls. In-depth understanding of the mechanisms of crystallization of calcifications in blood vessels is crucial for developing effective protective therapy. The paper presents the results of the thermodynamic calculation of the formation of calcification mineral phases and experimental results of phase formation under conditions typical of the human blood plasma prototype (inorganic composition). The regularities of nucleation in a model solution of human blood plasma under the conditions similar to physiological have been investigated. The induction order and constants are determined. It is shown that an increase in supersaturation leads to a transition from heterogeneous to homogeneous nucleation of crystallites. The critical nucleus size is estimated for a pure model system blood plasma. The kinetic regularities of crystallization (growth order and constants) in a model solution of blood plasma have been investigated. It is shown that the impurities affect to a greater extent the nucleation rather than the growth stage.
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References
Atkins P, De Paula Julio (2014) Physical chemistry: thermodynamics, structure, and change, 10th edn. W.H. Freeman and Company, New York
Elnikov VY, Rosseeva EV, Golovanova OA, Frank-Kamenetskaya OV (2007) Thermodynamic and experimental modeling of the formation of major mineral phases of uroliths. Russ J Inorg Chem 52:150–157
Engi M (1992) Thermodynamic data for minerals: a critical assessment. In: Price GD, Ross NL (eds) The stability of minerals. Kluwer Academic Publishers, Dordrecht
Frank-Kamenetskaya OV, Rozhdestvenskaya IV, Rosseeva EV, Zhuravlev AV (2014) Refinement of apatite atomic structure of albid tissue of late devon conodont. J Crystallogr Rep 59:41–47
Fridriksson T, Neuhoff PS, Viani BE, Bird DK (2004) Experimental determination of thermodynamic properties of ion-exchange in heulandite: binary ion exchange experiments at 55 and 85 ℃ involving Ca2+, Sr2+, Na+ and K+. Am J Sci 304:287–332
Füredi-Milhofer H (2010) Physiological and pathological mineralization: some problems and possible solutions. J Medicinski vjesnik 42:33–44
Furukawa K (2014) Recent advances in research on human aortic valve calcification. J Pharmacol Sci 124:129–137
Golovanova OA (2018) Thermodynamic modeling of poorly soluble compounds formation in biological fluid. J Therm Anal Calorim, 1219–1224
Golovanova OA, Chikanova ES (2015) Kinetic characteristics of crystallization from model solutions of the oral cavity. J Crystallogr Rep 60:970–978
Golovanova OA, Korol’kov VV (2017) Thermodynamics and kinetics of calcium oxalate crystallization in the presence of amino acids. J Crystallogr Rep 62:787–796
Golovanova OA, Solodyankina AA (2017a) Main features of nucleation in model solutions of blood plasma. J Crystallogr Rep 62:342–348
Golovanova OA, Solodyankina AA (2017b) Kinetic characteristics of the crystallization from model solutions of blood plasma. J Crystallogr Rep 62:497–503
Golovanova OA, Achkasova EY, Punin YO, Zhelyaev EV (2006) Main regularities of crystallization of calcium oxalate in the presence of amino acids. J Crystallogr Rep 51:348–354
Golovanova OA, Frank-Kamenetskaya OV, Punin YO (2011) Specific features of pathogenic mineral formation in the human body. Russ J Gen Chem 81:1392–1406
Golovanova OA, Chikanova ES, Malyshev AV, Mylnikova TS (2015) Data on granulometric composition of calcium phosphate obtained by dispersion method. In: IOP conference series: materials science and engineering, “International scientific conference on radiation-thermal effects and processes in inorganic materials”
Golovanova OA, Chikanova ES, Punin YO (2015b) Main features of nucleation in model solutions of oral cavity. J Crystallogr Rep 60:438–445
Golovanova O, Gerk S, Mylnikova T (2016) Biogenic, Abiogenic interactions in natural and anthropogenic systems, pp 443–460
Habraken W, Habibovic P, Epple M, Bohner M (2016) Calcium phosphates in biomedical applications: materials for the future? Mater Today, 69–87
He J, Lin R, Long H, Liang Y (2015) Adsorption characteristics of amino acids on to calcium oxalate. J Colloid Interface Sci 454:144–151
Indulekha P, Li S, Romay M et al (2017) Cardiac fibroblasts adopt osteogenic fates and can be targeted to attenuate pathological heart calcification. J Cell Stem Cell 20:218–232
Karwowski W, Naumnik B, Szczepański M, Myśliwiec M (2012) The mechanism of vascular calcification—a systematic review. J Med Sci Monit 18:1–11
Kazuyuki Y, Frank D, Kolodgie Fumiyuki O (2015) Pathophysiology of native coronary, vein graft, and in-stent atherosclerosis. J Nat Rev Cardiol 10:1038
Korolkov V, Golovanova O, Kuimova M (2016) Biogenic–abiogenic interactions in natural and anthropogenic systems, pp 485–500
Pak CY, Sakhaee K, Moe OW, Poindexter J (2011) Defining hypercalciuria in nephrolitiasis. Kidney Int 80:777–782
Pigozzi F (2011) Endothelial (dys)function: the target of physical exercise for prevention and treatment of cardiovascular disease. J Sports Med Phys Fitness 51:260–267
Plyasunova N, Plyasunov A, Shock E (2004) Database of thermodynamic properties for aqueous organic compounds. Int J Thermophys 25:351–360
Rabelo N, Knopf J, Fredel T et al (2015) Synthesis and characterization of calcium phosphate compounds with strontium and magnesium ionic substitutions. Int J Morphol 33:1189
Sajadi S (2010) Metal ion-binding properties of L-glutamic acid and L-aspartic acid, a comparative investigation. J Nat Sci 2:85–90
Schukin ED, Pertsov AV, Amelina EA (2016) Colloid chemistry: a textbook for bachelors, 7th ed, Rev and add. M. Yurait Publishing House. (In Russian)
Shanahan CM (2005) Mechanisms of vascular calcification in renal disease. J Clin Nephrol 63:146–157
Shock E, Sassini D, Willis M, Sverjensky D (1997) Inorganic species in geologic fluids: correlations among standard molal thermodynamic properties of aqueous ions and hydroxide complexes. J Geochim Cosmochim Acta 61:907–950
Sigel A, Sigel H, Sigel KO (2008) Biomineralization: from nature to application. Metal ions in life sciences. John Wiley
Solodyankina A, Nikolaev A, Frank-Kamenetskaya O, Golovanova O (2016) Synthesis and characterization of nanocrystalline apatites from solution modeling human blood. J Molec Struct 1119:484–489
Vaitheeswari S, Sriram R, Brindha P (2015) Studying inhibition of calcium oxalate stone formation: an in vitro approach for screening hydrogen sulfide and its metabolites. Int Braz J Urol 41:503–510
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The author thanks prof. Olga V. Frank-Kamenetskaya for helpful comments.
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Golovanova, O.A. (2020). Thermodynamics and Kinetics of Crystallization of Mineral Phases of Vascular Calcificates. In: Frank-Kamenetskaya, O., Vlasov, D., Panova, E., Lessovaia, S. (eds) Processes and Phenomena on the Boundary Between Biogenic and Abiogenic Nature. Lecture Notes in Earth System Sciences. Springer, Cham. https://doi.org/10.1007/978-3-030-21614-6_4
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