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Regenerative Treatments: Microneedling and PRP

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Hair and Scalp Treatments

Abstract

The treatment of hair disorders is an important part of clinical dermatology, given the prevalence of the problem and the great impact on patients’ quality of life. Many new treatments have been investigated in recent years, such as platelet-rich plasma (PRP) and microneedling, which have emerged as promising regenerative therapies.

These techniques were initially used by the medical community in fields other than dermatology; however, they have recently started to be popular among dermatologists for stimulating follicular regeneration. Several studies and case reports have demonstrated the therapeutic effectiveness of PRP and microneedling in hair loss disorders, but more evidence-based studies are needed to establish their real benefits.

Our experience leads us to suggest using these techniques in association with existing hair growth-promoting therapies, or alone when there are contraindications to medical treatments.

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References

  1. Kim YC, Park JH, Prausnitz MR. Microneedles for drug and vaccine delivery. Adv Drug Deliv Rev. 2012;64(1):547–68.

    Google Scholar 

  2. Ramaut L, Hoeksema H, Pirayesh A, Stillaert F, Monstrey S. Microneedling: where do we stand now? A systematic review of the literature. J Plast Reconstr Aestheth Surg. 2018;71(1):1–14.

    Article  Google Scholar 

  3. Dhurat R, Sukesh M, Avhad G, Dandale A, Pal A, Pund P. A randomized evaluator blinded study of effect of microneedling in androgenetic alopecia: a pilot study. Int J Trichology. 2013;5(1):6–11.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Dhurat R, Mathapati S. Response to microneedling treatment in men with androgenetic alopecia who failed to respond to conventional therapy. Indian J Dermatol. 2015;60(3):260–3.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Farid CI, Abdelmaksoud RA. Platelet rich plasma microneedling versus 5% topical minoxidil in the treatment of patterned hair loss. J Egypt Women’s Dermatol Soc. 2016;13:29–36.

    Article  Google Scholar 

  6. Sasaki GH. Microneedling depth penetration, presence of pigment particles, and fluorescein-stained platelets: clinical usage for aesthetic concerns. Aesthet Surg J. 2017;37:71–83.

    Article  PubMed  Google Scholar 

  7. Lee YB, Eun YS, Lee JH, et al. Effects of topical application of growth factors followed by microneedle therapy in women with female pattern hair loss: a pilot study. J Dermatol. 2013;40:81–3.

    Article  CAS  PubMed  Google Scholar 

  8. Lee JW, Yoo KH, Kim BJ, Kim MN. Photodynamic therapy with methyl-5-aminolevulinate acid combined with microneedle treatment in patients with extensive alopecia areata. Clin Exp Dermatol. 2009;35:548–9.

    Article  PubMed  Google Scholar 

  9. Chandrashekar B, Yepuri V, Mysone V. Alopecia areata-successful outcome with microneedling and triamcinolone acetonide. J Cutan Aesthet Surg. 2014;7:63–4.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Uebel CO, Da Silva JB, Cantarelli D, Martins P. The role of platelet plasma growth factors in male pattern baldness surgery. Plast Reconstr Surg. 2006;118:1458–66.

    Article  CAS  PubMed  Google Scholar 

  11. Gupta AK, Carviel J. A mechanism model of platelet-rich plasma treatment for androgenetic alopecia. Dermatol Surg. 2016;42:1335–9.

    Article  CAS  PubMed  Google Scholar 

  12. Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classification of platelet concentrates: from pure platelet-rich plasma (PRP) to leucocyte-and platelet-rich fibrin (L-PRF). Trends Biotechnol. 2009;2:158–67.

    Article  Google Scholar 

  13. Mishra A, Harmon K, Woodall J, Vieira A. Sports medicine applications of platelet rich plasma. Curr Pharm Biotechnol. 2012;13:1185–95.

    Article  CAS  PubMed  Google Scholar 

  14. Cervantes J, Perper M, Wong L, Eber A, Villasante Fricke A, Wikramanayake T, et al. Effectiveness of platelet-rich plasma for androgenetic alopecia: a review of the literature. Skin Appendage Disord. 2018;4:1–11.

    Article  PubMed  Google Scholar 

  15. Trink A, Sorbellini E, Bezzola P, et al. A randomized, double-blind, placebo-and active-controlled, half head study to evaluate the effects of platelet-rich plasma on alopecia areata. Br J Dermatol. 2008;159(1):1–22.

    Article  Google Scholar 

  16. El Taieb M, Ibrahim H, Nada E, Al-Din M. Platelets rich plasma versus minoxidil 5% in treatment of alopecia areata: a trichoscopic evaluation. Dermatol Ther. 2016;30:1–6.

    Google Scholar 

  17. Bolanča Ž, Goren A, Getaldić-Švarc B, Vučić M, Šitum M. Platelet-rich plasma as a novel treatment for lichen planopillaris. Dermatol Ther. 2016;29:233–5.

    Article  PubMed  Google Scholar 

  18. Shah KB, Shah AN, Solanki RB, Raval RC. A comparative study of microneedling with platelet-rich plasma plus topical minoxidil (5%) and topical minoxidil (5%) alone in androgenetic alopecia. Int J Trichology. 2017;9(1):14–8.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Jha AK, Udayan UK, Roy PK, Amar AKJ, Chaudhary RKP. Platelet-rich plasma with microneedling in androgenetic alopecia along with dermoscopic pre- and post-treatment evaluation. J Cosmet Dermatol. 2018;17:313–8.

    Article  PubMed  Google Scholar 

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Vincenzi, C., Marisaldi, B., Tosti, A. (2020). Regenerative Treatments: Microneedling and PRP. In: Tosti, A., Asz-Sigall, D., Pirmez, R. (eds) Hair and Scalp Treatments. Springer, Cham. https://doi.org/10.1007/978-3-030-21555-2_4

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  • DOI: https://doi.org/10.1007/978-3-030-21555-2_4

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-21554-5

  • Online ISBN: 978-3-030-21555-2

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