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Flexible Endoscopy: Early Detection of Dysplasia in Barrett’s Oesophagus

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Novel Optical Endoscopes for Early Cancer Diagnosis and Therapy

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Abstract

Barrett’s oesophagus is an acquired condition in which columnar epithelium replaces the stratified squamous epithelium of the lining of the distal oesophagus, the pipe which connects the throat to the stomach. Crucially for early detection attempts, Barrett’s oesophagus predisposes patients to the development of oesophageal adenocarcinoma, prompting the use of surveillance regimes to detect early malignancy for endoscopic therapy with curative intent. The currently accepted surveillance regime uses white light endoscopy together with random biopsies, but has poor sensitivity and discards information from numerous light–tissue interactions that could be exploited to probe structural, functional, and molecular changes in the tissue. The potential to improve clinical outcomes by increasing contrast for dysplasia with advanced optical techniques has driven a great deal of research in this area. In light of the translational characteristics and translational barriers presented in Chap. 1, advanced optical techniques are reviewed here in the context of identifying the most promising techniques to take forward in our own work.

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  1. Department of Physics and Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK

    Dr. Dale Jonathan Waterhouse

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Waterhouse, D.J. (2019). Flexible Endoscopy: Early Detection of Dysplasia in Barrett’s Oesophagus. In: Novel Optical Endoscopes for Early Cancer Diagnosis and Therapy. Springer Theses. Springer, Cham. https://doi.org/10.1007/978-3-030-21481-4_2

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