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Big from Small: MicroRNA in Relation to Veterinary Sciences

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Advances in Animal Biotechnology

Abstract

Eukaryotic transcriptome sequence data reveals that majority of the genome is transcribed into distinct noncoding RNA species, called microRNAs (miRNA). The miRNA is subset of tiny noncoding RNAs, about 21–23 nucleotides long, that play a role in controlling cognate mRNA degradation by cleavage or inhibiting the translational process. miRNA is popularly referred to as “micromanager of gene regulation.” In humans, miRNA disruption is correlated to diseases like cancers. In addition, miRNA has important implications in diseases and biological processes such as development, memory establishment, cell proliferation, apoptosis, and infections. Knowledge acquired from understanding miRNA pathway should be exploited to design artificial miRNAs with potential uses in therapeutics and livestock development.

Highlights

  • miRNAs are abundantly present in many organisms

  • The impact of miRNA-driven gene regulation is enormous; hence, it is a key field of study

  • In view of their involvements in diseases and biological processes, miRNAs offer opportunities to develop curative interventions.

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Author information

Authors and Affiliations

  1. ICAR-Indian Veterinary Research Institute, Regional Station, Palampur, India

    Birbal Singh & Gorakh Mal

  2. Department of Biotechnology, Kurukshetra University, Kurukshetra, Haryana, India

    Sanjeev K. Gautam

  3. Department of Animal Biotechnology, ICAR-National Bureau of Animal Genetic Resources, Karnal, Haryana, India

    Manishi Mukesh

Authors
  1. Birbal Singh
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  2. Gorakh Mal
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  3. Sanjeev K. Gautam
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  4. Manishi Mukesh
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Corresponding author

Correspondence to Birbal Singh .

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Singh, B., Mal, G., Gautam, S.K., Mukesh, M. (2019). Big from Small: MicroRNA in Relation to Veterinary Sciences. In: Advances in Animal Biotechnology. Springer, Cham. https://doi.org/10.1007/978-3-030-21309-1_41

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