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RNA Interference: A Veterinary Health Perspective

  • Birbal SinghEmail author
  • Gorakh Mal
  • Sanjeev K. Gautam
  • Manishi Mukesh
Chapter
  • 547 Downloads

Abstract

RNA interference (RNAi) is a naturally evolved and a conserved self-defensive mechanism triggered by double-stranded RNA (dsRNA) that limits transcript levels either by suppressing transcription or activating sequence-specific degradation of RNA. RNAi protects the host from endogenous and exogenous invading nucleic acids by regulating gene expression. RNAi is used as a promising tool in functional genomics and targeting microbial infections.

Highlights

  • RNAi is a natural mechanism of self-defense in living organisms

  • RNAi is used as a tool to prevent zoonotic infections and non-infectious diseases.

Keywords

RNAi RNA isoforms Virus Bacteria Vaccines Gene suppression CRISPR/Cas-9 Drosophila melanogaster 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Birbal Singh
    • 1
    Email author
  • Gorakh Mal
    • 1
  • Sanjeev K. Gautam
    • 2
  • Manishi Mukesh
    • 3
  1. 1.ICAR-Indian Veterinary Research Institute, Regional StationPalampurIndia
  2. 2.Department of BiotechnologyKurukshetra UniversityKurukshetraIndia
  3. 3.Department of Animal BiotechnologyICAR-National Bureau of Animal Genetic ResourcesKarnalIndia

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