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Milk is an important component of nutrition of human and animal neonates and has attracted interest of food technologists, clinicians, and biochemists. Composition of milk can be modified by dietary manipulations of milch animals and altering the genetic make-up of milk-producing species.
Milk can be modified by dietary and genetic manipulation
Milk having modified constituents has applications to improve health.
KeywordsMilk Milk derived therapeutics Transgenic animals Milk composition
- Bainbridge ML, Saldinger LK, Barlow JW, Alvez JP, Roman J, Kraft J (2018) Alteration of rumen bacteria and protozoa through grazing regime as a tool to enhance the bioactive fatty acid content of bovine milk. Front Microbiol 9:904. https://doi.org/10.3389/fmicb.2018.00904 (eCollection)CrossRefPubMedPubMedCentralGoogle Scholar
- Henno M, Ariko T, Kaart T, Kuusik S, Ling K, Kass M, Jaakson H, Leming R, Givens DI, Sterna V, Ots M (2018) The fatty acid composition of Estonian and Latvian retail milk; implications for human nutrition compared with a designer milk. J Dairy Res 85(2):247–250. https://doi.org/10.1017/S0022029918000183CrossRefPubMedGoogle Scholar
- Jochum F, Alteheld B, Meinardus P, Dahlinger N, Nomayo A, Stehle P (2017) Mothers’ consumption of soy drink but not black tea increases the flavonoid content of term breast milk: a pilot randomized, controlled intervention study. Ann Nutr Metab 70(2):147–153. https://doi.org/10.1159/000471857 (Epub 2017 Apr 8)CrossRefPubMedGoogle Scholar
- Krimpenfort P, Rademakers A, Eyestone W, van der Schans A, van den Broek S, Kooiman P, Kootwijk E, Platenburg G, Pieper F, Strijker R et al (1991) Generation of transgenic dairy cattle using ‘in vitro’ embryo production. Biotechnology (NY) 9(9):844–847Google Scholar
- Maga EA, Cullor JS, Smith W, Anderson GB, Murray JD (2006) Human lysozyme expressed in the mammary gland of transgenic dairy goats can inhibit the growth of bacteria that cause mastitis and the cold-spoilage of milk. Foodborne Pathog Dis 3(4):384–392. https://doi.org/10.1089/fpd.2006.3.384CrossRefPubMedGoogle Scholar
- Menchaca A, Anegon I, Whitelaw CB, Baldassarre H, Crispo M (2016) New insights and current tools for genetically engineered (GE) sheep and goats. Theriogenology 86(1):160–169. https://doi.org/10.1016/j.theriogenology.2016.04.028 (Epub. Review)CrossRefGoogle Scholar
- Monaco MH, Gronlund DE, Bleck GT, Hurley WL, Wheeler MB, Donovan SM (2005) Mammary specific transgenic over-expression of insulin-like growth factor-I (IGF-I) increases pigmilk IGF-I and IGF binding proteins, with no effect on milk composition or yield. Transgenic Res 14(5):761–773CrossRefGoogle Scholar
- Nature Biotechnology (2014) Rabbit milk Ruconest for hereditary angioedema. 32:849. https://doi.org/10.1038/nbt0914-849d
- Wang S, Deng S, Cao Y, Zhang R, Wang Z, Jiang X, Wang J, Zhang X, Zhang J, Liu G, Lian Z (2018) Overexpression of toll-like receptor 4 contributes to phagocytosis of salmonella enterica serovar typhimurium via phosphoinositide 3-kinase signaling in sheep. Cell Physiol Biochem 49(2):662–677. https://doi.org/10.1159/000493032 (Epub 2018 Aug 30)CrossRefPubMedGoogle Scholar
- Wei J, Wagner S, Maclean P, Brophy B, Cole S, Smolenski G, Carlson DF, Fahrenkrug SC, Wells DN, Laible G (2018) Cattle with a precise, zygote-mediated deletion safely eliminate the major milk allergen beta-lactoglobulin. Sci Rep 8(1):7661. https://doi.org/10.1038/s41598-018-25654-8CrossRefPubMedPubMedCentralGoogle Scholar
- Wolf E, Jehle PM, Weber MM, Sauerwein H, Daxenberger A, Breier BH, Besenfelder U, Frenyo L, Brem G (1997) Human insulin-like growth factor I (IGF-I) produced in the mammary glands of transgenic rabbits: yield, receptor binding, mitogenic activity, and effects on IGF-binding proteins. Endocrinology 138(1):307–313CrossRefGoogle Scholar