Transgenesis and Genetically Engineered Livestock as Live Bioreactors

  • Birbal SinghEmail author
  • Gorakh Mal
  • Sanjeev K. Gautam
  • Manishi Mukesh


Transgenic animals are important components of modern biomedical and veterinary sciences. They produce recombinant proteins, enzymes and antibodies for treating diseases and serve as models for disease research, diagnosis, and prevention. A number of genetically engineered or recombinant products are currently obtained from animals, and some have been approved for humans use. With advances in precise genetic engineering and genome editing and producing cloned gene-edited animals, it is possible to produce larger quantities of recombinant proteins and biologics from transgenic animals.

  • The art of producing transgenic or genome-edited livestock has metamorphosed during recent two decades

  • Animals contribute to human health by producing recombinant biomolecules and serving as model animals.


Transgenic animals Bioreactors Recombinant therapeutics Biopharming Gene-editing 


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Birbal Singh
    • 1
    Email author
  • Gorakh Mal
    • 1
  • Sanjeev K. Gautam
    • 2
  • Manishi Mukesh
    • 3
  1. 1.ICAR-Indian Veterinary Research Institute, Regional StationPalampurIndia
  2. 2.Department of BiotechnologyKurukshetra UniversityKurukshetraIndia
  3. 3.Department of Animal BiotechnologyICAR-National Bureau of Animal Genetic ResourcesKarnalIndia

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