Oogonia Stem Cells in Farm Animals
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The oogonia stem cells (OSCs) are the founding female germ stem cells that differentiate into oogonia and oocytes. The OSCs serve as the carrier of genetic information from mother to offspring. The insights from intraovarian transplantation in experimental animals reveal the capacity of OSCs to generate functional oocytes that can be fertilized and support fetal development and birth of offspring.
The OSCs are the founding unipotent female germ stem cells
They generate oogonia and oocytes that can produce viable offspring.
KeywordsOogonia stem cells Germ cells Oocytes Livestock oogonia
- Clarkson YL, McLaughlin M, Waterfall M, Dunlop CE, Skehel PA, Anderson RA, Telfer EE (2018) Initial characterisation of adult human ovarian cell populations isolated by DDX4 expression and aldehyde dehydrogenase activity. Sci Rep 8(1):6953. https://doi.org/10.1038/s41598-018-25116-1CrossRefPubMedPubMedCentralGoogle Scholar
- Johnson J, Canning J, Kaneko T, Pru JK, Tilly JL (2004) Germline stem cells and follicular renewal in the postnatal mammalian ovary. Nature 428(6979):145–150. Erratum in: Nature (2004) 430(7003):1062Google Scholar
- Silvestris E, Cafforio P, D’Oronzo S, Felici C, Silvestris F, Loverro G (2018) In vitro differentiation of human oocyte-like cells from oogonial stem cells: single-cell isolation and molecular characterization. Hum Reprod 33(3):464–473. https://doi.org/10.1093/humrep/dex377CrossRefPubMedGoogle Scholar
- Woods DC, White YA, Niikura Y, Kiatpongsan S, Lee HJ, Tilly JL (2013b) Embryonic stem cell-derived granulosa cells participate in ovarian follicle formation in vitro and in vivo. Reprod Sci 20(5):524–535. https://doi.org/10.1177/1933719113483017 (Epub 2013 Mar 27)CrossRefPubMedPubMedCentralGoogle Scholar