Abstract
Late diagnosis in patients with X-linked agammaglobulinemia (XLA) is associated with irreversible pulmonary complications such as bronchiectasis
-
Simple screening methods, such as serum protein fractions may be useful in suspecting of antibody deficiency
-
Medical treatment for XLA is by lifelong immunoglobulin replacement using Intravenous immunoglobulin (IVIG) or subcutaneous immunoglobulin (SCIG)
-
Use of plasma for immunoglobulin substitution is dangerous due to possibility of transmission of blood-borne infections
-
It is necessary to remember the inexpediency of serological tests is suspicion of infections and using only direct methods of detecting the pathogen
Keywords
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
de Vries E. Patient-centred screening for primary immunodeficiency: a multi-stage diagnostic protocol designed for non-immunologists. Clin Exp Immunol. 2006;145(2):204–14.
O’Connell TX, Horita TJ, Kasravi B. Understanding and interpreting serum protein electrophoresis. Am Fam Physician. 2005;71(1):105–12.
Serum protein electrophoresis. [database on the Internet]. Accessed: Retrieved 2 Oct 2013.
Reale M, Iarlori C, Feliciani C, Gambi D. Peripheral chemokine receptors, their ligands, cytokines and Alzheimer’s disease. J Alzheimer’s Dis. 2008;14(2):147–59.
Quinti I, Soresina A, Guerra A, Rondelli R, Spadaro G, Agostini C, Milito C, Trombetta AC, Visentini M, Martini H, Plebani A, Fiorilli M. Effectiveness of immunoglobulin replacement therapy on clinical outcome in patients with primary antibody deficiencies: results from a multicenter prospective cohort study. J Clin Immunol. 2011;31(3):315–22.
Abolhassani H, Sadaghiani MS, Aghamohammadi A, Ochs HD, Rezaei N. Home-based subcutaneous immunoglobulin versus hospital-based intravenous immunoglobulin in treatment of primary antibody deficiencies: systematic review and meta analysis. J Clin Immunol. 2012;32(6):1180–92.
Bezrodnik L, Gomez Raccio A, Belardinelli G, Regairaz L, Diaz Ballve D, Seminario G, Moreira I, Riganti C, Cantisano C, Diaz H, Di Giovanni D. Comparative study of subcutaneous versus intravenous IgG replacement therapy in pediatric patients with primary immunodeficiency diseases: a multicenter study in Argentina. J Clin Immunol. 2013;33(7):1216–22.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Bondarenko, A., Chernyshova, L. (2019). Brothers with Recurrent Sinopulmonary Infections and Chronic Lung Disease. In: Rezaei, N. (eds) Pediatric Immunology. Springer, Cham. https://doi.org/10.1007/978-3-030-21262-9_9
Download citation
DOI: https://doi.org/10.1007/978-3-030-21262-9_9
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-21261-2
Online ISBN: 978-3-030-21262-9
eBook Packages: MedicineMedicine (R0)