Abstract
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Hyper IgE syndrome (HIES) should be considered when a patient presents with elevated IgE levels, eczema, recurrent skin abscesses and pneumonia
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DOCK8 deficiency should be considered in any patient with immunodeficiency and a history of atopy (i.e. allergic rhinitis, food allergies, asthma) and elevated IgE
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Patients with DOCK8 deficiency are at increased risk of malignancy secondary to cutaneous viral infections. This is due to susceptibility of DOCK8-deficient T and NK cells to cytothripsis during migration through collagen-dense tissues
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Definitive cure is hematopoietic stem cell transplantation which leads to immune reconstitution and reversal of clinical phenotypes
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Seghezzo, S., Dorsey, M. (2019). Rash and Several Food Allergies. In: Rezaei, N. (eds) Pediatric Immunology. Springer, Cham. https://doi.org/10.1007/978-3-030-21262-9_45
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DOI: https://doi.org/10.1007/978-3-030-21262-9_45
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