Abstract
Functional antibodies like anti-blood group antibodies, anti-candida and E-coli antibodies usually develop around first year of life and cannot be used for severe combined immunodeficiency (SCID) screening
Any family having unexplained death of infants should get its newborns screened for primary immunodeficiency
Main role of DCLRE1C gene is that it encodes Artemis, a nuclease involved in non-homologous end joining and opening of hairpins arising from VDJ recombination of immunoglobulin and T cell receptor (TCR) genes. Mutations in this gene lead to defective VDJ recombination leading to failure of lymphocyte development
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Tipu, H.N., Bainter, W. (2019). Recurrent Respiratory Tract Infections. In: Rezaei, N. (eds) Pediatric Immunology. Springer, Cham. https://doi.org/10.1007/978-3-030-21262-9_36
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DOI: https://doi.org/10.1007/978-3-030-21262-9_36
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