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Immune Basis of Food Protein-Induced Enterocolitis Syndrome

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Food Protein Induced Enterocolitis (FPIES)

Abstract

Food protein-induced enterocolitis syndrome, or FPIES, is a non-IgE-mediated food allergy that presents in infancy and is outgrown in most but not all individuals in the first few years of life. It has commonly been referred to as a cell-mediated food allergy, but the pathophysiology of the disease remains difficult to explain, and there is a lack of conclusive evidence for a role of antigen-specific humoral or cellular immunity in FPIES. However, it is clearly an inflammatory disease triggered by specific foods. In this chapter, the evidence for an immune basis of FPIES will be reviewed.

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Acknowledgments

Thanks to Ms. Lisette Peres for research assistance in the preparation of this manuscript.

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Authors and Affiliations

  1. Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    M. Cecilia Berin

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  1. M. Cecilia Berin
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Correspondence to M. Cecilia Berin .

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Editors and Affiliations

  1. Division of Allergy and Immunology, University of Pennsylvania, Perelman School of Medicine, Children’s Hospital of Philadelphia, Philadelphia, PA, USA

    Terri Faye Brown-Whitehorn

  2. Division of Allergy and Immunology, University of Pennsylvania, Perelman School of Medicine, Children’s Hospital of Philadelphia, Philadelphia, PA, USA

    Antonella Cianferoni

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Berin, M.C. (2019). Immune Basis of Food Protein-Induced Enterocolitis Syndrome. In: Brown-Whitehorn, T., Cianferoni, A. (eds) Food Protein Induced Enterocolitis (FPIES). Springer, Cham. https://doi.org/10.1007/978-3-030-21229-2_3

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  • DOI: https://doi.org/10.1007/978-3-030-21229-2_3

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-21228-5

  • Online ISBN: 978-3-030-21229-2

  • eBook Packages: MedicineMedicine (R0)

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