Abstract
Food protein-induced enterocolitis syndrome (FPIES) has historically been regarded as a rare non-IgE-mediated gastrointestinal disorder. Initial case series were infrequent and contained small numbers of patients; however, with time, more allergy clinics from around the world are reporting their experience with FPIES. The exact incidence and prevalence of FPIES remain unknown. Studies conducted thus far have permitted identification of key features of this disorder’s presentation within the population. Chronic FPIES typically presents in neonates less than 2 months of age, whereas acute FPIES presents in infants between 2 and 7 months of age. Few risk factors have definitively been associated with the development of FPIES; however, it does seem to be associated with a family history of atopic disease as well as a history of cesarean birth and personal atopic disease. Males are slightly more affected than females. The existing case studies illustrate that there is significant regional variation in the common triggering foods, as well as the rate of combined milk and soy FPIES and multifood FPIES. The exact extent an underlying mechanism of this regional variation remains unclear and requires further study. The recent development of international consensus guidelines for the diagnosis of FPIES as well as an ICD-10 code for FPIES will help standardized future epidemiological studies. In this chapter, we review the impact that epidemiologic studies of FPIES have contributed thus far and highlight current unanswered questions within the field.
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Ruffner, M.A., Spergel, J.M. (2019). Epidemiology of Food Protein-Induced Enterocolitis Syndrome. In: Brown-Whitehorn, T., Cianferoni, A. (eds) Food Protein Induced Enterocolitis (FPIES). Springer, Cham. https://doi.org/10.1007/978-3-030-21229-2_2
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DOI: https://doi.org/10.1007/978-3-030-21229-2_2
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