Abstract
Aquatic organism dormancy has interesting medical applications, which include dormancy in parasite species, dormancy in intermediate hosts of parasites, and several diseases that seem to present a kind of dormancy. Among these, the most remarkable is the state of dormancy in some types of cancer, one of the most serious human diseases. Holmes, in the middle of the twentieth century, recognized, as one stage of cancer, a long period of delay in carcinogenesis, similar to dormancy. Later on, Makrushin described an “evolutionary hypothesis” of carcinogenesis and recognized this disease as an old genetically related program—a kind of archaic program that is normally dependent on “sleeping” genes. His hypothesis did not explain several important peculiarities of cancerous tumors. The most important one is fast dissemination of the tumor and creation of a large number of metastases. In this chapter, we suggest another hypothesis of carcinogenesis, also related to sleeping genes, that is responsible for the metabolic rate found in dormant cells and postdiapause cells. A possible hormonal mechanism underlying this hypothesis is discussed.
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Acknowledgements
We acknowledge financial support from Taiwan (NSC 94-231 l-B-019-009) and Russia (05-04-90588-HHC_a, 17-04-00027) in a bilateral collaboration. The study was partly supported by the Russian Academy of Science (topics 65.4 and 65.5).
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Tseng, MH., Hwang, JS., Alekseev, V.R. (2019). Aquatic Invertebrate Dormancy and Medicine. In: Alekseev, V., Pinel-Alloul, B. (eds) Dormancy in Aquatic Organisms. Theory, Human Use and Modeling. Monographiae Biologicae, vol 92. Springer, Cham. https://doi.org/10.1007/978-3-030-21213-1_11
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DOI: https://doi.org/10.1007/978-3-030-21213-1_11
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