A Historical Perspective on Evolving Concepts of Cardiorenal Syndrome in Heart Failure

  • Joshua Grant
  • Hector O. VenturaEmail author


Cardiorenal syndrome, the clinical process that describes the interaction between the heart and the kidneys, has recently received a great deal of attention from clinical and research standpoints. Patients that have heart and kidney problems are common today in clinical practice and the presence of cardiorenal abnormalities is associated with high morbidity and mortality. The concept of cardiorenal syndrome is however not novel. Thus, it is critical to re-examine efforts of the past. The trials and tribulations of yesterday’s clinical investigators are important and give us greater insight into today’s practice. In this narrative, we sought to report a historical overview of cardiorenal interactions and thus render homage to those physicians dedicating their work to this subject. Those physicians have paved the way to an era in which the concept, consequences and pathophysiology of cardiorenal syndrome is much better understood.


Cardiorenal Historical overview Evolving concepts 


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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.PeaceHealth System ServicesVancouverUSA
  2. 2.The John Ochsner Heart and Vascular Institute Ochsner Clinical SchoolNew OrleansUSA
  3. 3.The University of Queensland School of MedicineBrisbaneAustralia

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