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Asian Conference on Computer Vision

ACCV 2018: Computer Vision – ACCV 2018 pp 625–640Cite as

DeepAMD: Detect Early Age-Related Macular Degeneration by Applying Deep Learning in a Multiple Instance Learning Framework

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Part of the book series: Lecture Notes in Computer Science ((LNIP,volume 11365))

Abstract

Automatic screening of Age-related Macular Degeneration (AMD) is important for both patients and ophthalmologists. In this paper, we focus on the task of AMD detection at the very early stage from fundus images. The difficulty of this task is that at the very early stage, the signs, e.g., drusen, are too tiny and subtle to be detected by most of the current methods. To address this issue, we apply deep learning in a multiple instance learning framework to catch these subtle features to detect AMD at the very early stage. The deep networks is able to learn a discriminative representation of the subtle signs of AMD. The multiple instance learning framework helps in two ways. First, It is able to choose the location where AMD happens because it works on image patches instead of the whole image. Second, It works on the image of high resolution instead of down sampling the image which may lead to invisibility of the tiny drusen. The experiments are carried out on a dataset consists of 3596 AMD and 1129 normal fundus images. The final average AUC is 0.79, compared with 0.74 of the same neural network but without multiple instance learning.

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Authors and Affiliations

  1. Institute for Infocomm Research, A*STAR, Singapore, Singapore

    Huiying Liu, Damon W. K. Wong & Huazhu Fu

  2. Artificial Intelligence Innovation Business, Baidu Inc., Beijing, China

    Yanwu Xu

  3. Cixi Institute of Biomedical Engineering, Ningbo Institute of Industrial Technology, Chinese Academy of Sciences, Beijing, China

    Jiang Liu

Authors
  1. Huiying Liu
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  2. Damon W. K. Wong
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  3. Huazhu Fu
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  4. Yanwu Xu
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  5. Jiang Liu
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Corresponding author

Correspondence to Yanwu Xu .

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Editors and Affiliations

  1. IIIT Hyderabad, Hyderabad, India

    C.V. Jawahar

  2. ANU, Canberra, ACT, Australia

    Hongdong Li

  3. Simon Fraser University, Burnaby, BC, Canada

    Greg Mori

  4. ETH Zurich, Zurich, Zürich, Switzerland

    Konrad Schindler

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Cite this paper

Liu, H., Wong, D.W.K., Fu, H., Xu, Y., Liu, J. (2019). DeepAMD: Detect Early Age-Related Macular Degeneration by Applying Deep Learning in a Multiple Instance Learning Framework. In: Jawahar, C., Li, H., Mori, G., Schindler, K. (eds) Computer Vision – ACCV 2018. ACCV 2018. Lecture Notes in Computer Science(), vol 11365. Springer, Cham. https://doi.org/10.1007/978-3-030-20873-8_40

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  • DOI: https://doi.org/10.1007/978-3-030-20873-8_40

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-20872-1

  • Online ISBN: 978-3-030-20873-8

  • eBook Packages: Computer ScienceComputer Science (R0)

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